ID A0A1Y2T3H6_SYMTR Unreviewed; 334 AA.
AC A0A1Y2T3H6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 03-MAY-2023, entry version 16.
DE SubName: Full=Adenosylhomocysteinase {ECO:0000313|EMBL:OTA40879.1};
DE Flags: Fragment;
GN ORFNames=A6D92_12270 {ECO:0000313|EMBL:OTA40879.1};
OS Symbiobacterium thermophilum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Symbiobacteriaceae;
OC Symbiobacterium.
OX NCBI_TaxID=2734 {ECO:0000313|EMBL:OTA40879.1, ECO:0000313|Proteomes:UP000194267};
RN [1] {ECO:0000313|Proteomes:UP000194267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Antunes L.P., Martins L.F., Pereira R.V., Thomas A.M., Barbosa D.,
RA Nascimento L., Silva G.M., Condomitti G.W., Digiampietri L.A.,
RA Lombardi K.C., Ramos P.L., Quaggio R.B., Oliveira J.C., Pascon R.C.,
RA Cruz J.B., Silva A.M., Setubal J.C.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OTA40879.1}.
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DR EMBL; LWLV01001063; OTA40879.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2T3H6; -.
DR Proteomes; UP000194267; Unassembled WGS sequence.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00401; SAHH; 1.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR Pfam; PF05221; AdoHcyase; 2.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00738; ADOHCYASE_1; 1.
DR PROSITE; PS00739; ADOHCYASE_2; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT DOMAIN 190..334
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
FT NON_TER 334
FT /evidence="ECO:0000313|EMBL:OTA40879.1"
SQ SEQUENCE 334 AA; 36062 MW; 6899C585E365FB1F CRC64;
MPSKVSASTL RDPALAPSGH QKIDWVRAHM PILNQLEREL GEKKPLAGQR VAMSIHLEAK
TAYMALVFAA AGAEVFLTGS NPLSTQDDVA AAVAERGVTV HAWRGATPAE YREHLIRTLE
AARPTLLLDD GGDLTHLLHT SHADLAADLI GGSEETSTGV QRLRAMEAEG VLRFPMVAVN
NARMKHLFDN RYGTGQSTLE SIMRNTNLSI AGKRVVVAGY GWCGKGVAMR ARGLGARVIV
CEVDPVRANE ALMDGFEVMP MARAAALGDI FITVTGCEKV IRGEHFAVMR DGAILANAGH
FDVEIWKPDL EAFGGKPVRV RPNVDQYTAP DGRR
//
