ID A0A1Y2URM6_9PEZI Unreviewed; 799 AA.
AC A0A1Y2URM6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OTA86706.1};
GN ORFNames=M434DRAFT_81922 {ECO:0000313|EMBL:OTA86706.1};
OS Hypoxylon sp. CO27-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001938 {ECO:0000313|EMBL:OTA86706.1, ECO:0000313|Proteomes:UP000194361};
RN [1] {ECO:0000313|EMBL:OTA86706.1, ECO:0000313|Proteomes:UP000194361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO27-5 {ECO:0000313|EMBL:OTA86706.1,
RC ECO:0000313|Proteomes:UP000194361};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
CC -!- SIMILARITY: In the 2nd section; belongs to the type-I 3-dehydroquinase
CC family. {ECO:0000256|ARBA:ARBA00006477}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the shikimate kinase
CC family. {ECO:0000256|ARBA:ARBA00009349}.
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DR EMBL; KZ112567; OTA86706.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2URM6; -.
DR STRING; 1001938.A0A1Y2URM6; -.
DR Proteomes; UP000194361; Unassembled WGS sequence.
DR GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:InterPro.
DR GO; GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity; IEA:InterPro.
DR CDD; cd01065; NAD_bind_Shikimate_DH; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR001381; DHquinase_I.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR013708; Shikimate_DH-bd_N.
DR InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR PANTHER; PTHR21090; AROM/DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR21090:SF17; QUINATE REPRESSOR PROTEIN; 1.
DR Pfam; PF01487; DHquinase_I; 1.
DR Pfam; PF01488; Shikimate_DH; 1.
DR Pfam; PF08501; Shikimate_dh_N; 1.
DR Pfam; PF01202; SKI; 1.
DR PRINTS; PR01100; SHIKIMTKNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000194361}.
FT DOMAIN 475..554
FT /note="Shikimate dehydrogenase substrate binding N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08501"
FT DOMAIN 610..658
FT /note="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA
FT reductase"
FT /evidence="ECO:0000259|Pfam:PF01488"
SQ SEQUENCE 799 AA; 90204 MW; 4D7C87EF7CF47411 CRC64;
MIPDSPIIPS SRTKRRIFHA DASIILVGCR GAGKRTLGFI AAKHLGRRLI TEDHSFEQAT
GCTRATFLQK YGRETFNQQM AIVLARMIKP NQTNCVIECG TGTLSPAIEE ILKGYLETNP
IIYIHRDKED LYKLLKLPVT DAEPLLIADQ KHRDFSNLEY FNVYDPSGEG HVTEDIPLRS
ALTSSARLVD AKQDFKNFLD SIFGHSLTRS WVSNPFSIKA IPPEYRTYTY VLHLRLSTLI
NINVDLAKLE APGEAVEFII DTWPNNMLDI IATQVALIRH KMDVPIIYNV EENPREERKR
PIEERDAADL ELMLHGFRLG VEYLTLDLER SPHLVTHVLA MRGRTKIIGN YVARGFGAPK
WTDDFYIERY LYAQRLGCNI VRIARFCAAA RDDSLRQAFV DRIRALPDPK PCLIAYDYSV
FGVVLPFQDK IMNPVGHDSL EKSSREQMAG VSTTRGSLRD VFRKGYLQPL NFYTLGSNVY
YSASPSMHRA AYEHYMMPHT FDARRCTTLE EVDRIRQEPG FGGASLTAPF KVAIMKHLDH
LSTHAIAIGA VNTLLPLRGE TDSILDHANS RNRAGVASKF YGDNTDWSSI VTCLRRAISP
RNSVQPSRTT GLVIGAGGMA RAAIYALIKL GCRMIFIHNR TKAKAEEVAR HFNTYALEQK
LVRQNDGELI CHVIESPRDP WPDSYQPPTM IVSCIPASGV DDNPPVDFRM PSQWLKSPTG
GVVIELAYEP LITPLVVQVR KIREEGNTSW VIVDGLEVVG EMAMEAFELM TGRQAPRRLM
RRVCNETWEK TCAPFQPQR
//
