ID A0A1Y2UW62_9PEZI Unreviewed; 2675 AA.
AC A0A1Y2UW62;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=M434DRAFT_398766 {ECO:0000313|EMBL:OTA89178.1};
OS Hypoxylon sp. CO27-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001938 {ECO:0000313|EMBL:OTA89178.1, ECO:0000313|Proteomes:UP000194361};
RN [1] {ECO:0000313|EMBL:OTA89178.1, ECO:0000313|Proteomes:UP000194361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO27-5 {ECO:0000313|EMBL:OTA89178.1,
RC ECO:0000313|Proteomes:UP000194361};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
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DR EMBL; KZ112537; OTA89178.1; -; Genomic_DNA.
DR STRING; 1001938.A0A1Y2UW62; -.
DR Proteomes; UP000194361; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 6.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR022716; Gcn1_N.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR Pfam; PF12074; Gcn1_N; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000194361};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1344..1580
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1521..1559
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 1664..1917
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1981..2018
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 2633..2652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2675 AA; 291570 MW; E221B258EEF0E770 CRC64;
MTEAAANGAS KAGIDPSSAR AALFSSSTKT RIAQLRAIDE KLRDKTIDQS SISALLQLLF
DTHRFYDDRS SRRAADTCLV SIFATTTDPK VLAPFISSVR QEAQKPGIAP KSAFVLVEWC
SVLLQGLAGN PLWDKFGLEI IHANAAALEK CLQPTTRPSV AQSALVVTRR GLRAAFWRNG
FREKAIQDAV QALTAKGAQP TARNAIILGV IAGVCSRHAQ AKNALTAKKS EYFTFFTREL
VGSRTPVPAH IATGLRDFFS DFITLEDLDK DIIPPIEKGL LRAPEVVLDL VALLIRALPK
ELDLSQTLNG RLLKPLLSNA KSSNATIREG VLAAFREAVA RSHDAKLTDQ VAEEILNPLK
SGKLASADHR ILHSQMLEHV PLSKSIASKI ATGLPPIATK EGNEGALGEE ISVISRSVSY
LLTDGTELPK PVVDAFTKGL GDKKIPSRRL WLLRVGEIFI PFTGDAQSVP PNAIKLAEAI
AGPVAETWAE IIKNPAAAAQ SGLIVGAYVF STLALKVLSK IDSTPLKAVL KKTAVSKECL
VADPKPSFLL NHRVYSRLST EDDTRWFLRA LTAVYDDVSK APQNVQVAWF QAFIYLVSST
SVPSQIRKET CDTISKLYVR DPDFISDIAI SSLWRWIESS HTEEKDSIAA HAKFEDAHLH
LVLRSICLND EEFKELGAQK PQEQLAKQMC SLLVIARNDL IPRASWINLC LRVGLDPGSL
AQKYEKELIQ QVIDKTSFDQ KSKAIKLAAC NAAADLAFVA PDTVTPKIVE LIRTDLATDD
LKEVGPVEAA IFRTPEGTAF IDVLSKKQTL PDKNTKDYDT LKWEEELRSQ LAQKKGQQRK
LTADEQAKVN AQLKKESEIR RSIQRLESRL MRGFGIIRSL VNTPPTEPNL WIGPSISALL
GALEAGAGLI TGDAGPNAYL ACSERVTPRL GAIRPFIGIA TLRALGITSL PENLTEEGLE
ELVTRVLYRL RFAGEQRPFD TVSVIYMLSL IFVILRTGGI GAGADERDAQ LVLAIEFLSF
HTHVCTDETI PRADLISILI SSMQQYNQHY KIIKDCFSDM IRCVAPNISA DEIAVLAKGA
IVPQASVRET VLQSISAEID MSDLTFSEEI WIACHDDILE NIELGREIWE ESGFKLSKDV
PFKILPYIES KDAQLRRAAA RALAEACRAF PLTIEDVLKR LRSSYVEFAK PRVPQLDEYG
MPKKTDLSDP WEARHGIGAA FRELAAHLQK SQIDDFFNFL IEGGPLGDQN AAVRSEMLEA
ALVAIDLHGR ALVDKLMKTF ERTLGAPDKG SEAADRVNEA VIIMYGALAR HLKPGDAKIP
VVLERLLATL STPSEAVQYA VAECLPPLVR TCGDKSSKYF DQVLDTLLNS KKYAEKRGAA
YGLAGLVQGR GISVLREYRI LITLKSATEN KKEPQQREGA FLAFELLATI LGRLFEPYVI
QIVPQLLAGF GDSNADVRDA CLAAAKACFA KLSSYGVKQI LPTLLNGLDD DQWRSKRGAC
DLLGAMAYLD PQQLAQSLPD IIPPLTGVLN DSHKEVRTAA NKSLKRFGEV IENPEVKSLV
DILLKALSDP TKYTDDALDA LIKVQFVHYL DAPSLALVTR ILQRGLGDRS NTKRKAAQVI
GSLAHLTERK DLIAHLPVLV SGLKLAAVDP VPTTRATASR ALGSLVEKLG EDALPDLIPG
LMQTLKSDTG AGDRLGSAQA LSEVLAGLGT TRLEETLPTI LQNVESPKPA VREGFMSLFI
FLPVCFGNSF ANYLGKIIPP ILAGLADDIE SIRETALRAG RLLVKNFAAR AVDLLLPELE
RGLADDNYRI RLSSVELVGD LLFNLTGISG KADAEDEQES AKEAGASLRE VLGEDKRNRI
LSALYICRCD TSSAVRAAAV SVWKALVATP RTLKELTPTL TQLIIRRLGS SNMEHKVIAS
NALGELIRKA GDGVLSSLLP TLEEGLQISI DTNARQGICL ALKELISSAS EEALEDHEKT
LISVVRTALT DSDEDVREAA AEAFDSLQQI IGKRAVDQVL PYLLNLLRSE DEADNALSAL
LTLLTETTRS NIILPNLIPT LITPPISAFN ARALASLSRV AGPAMNRRLP NIINSLMDNI
VSTKDEELRV ELENAFDTVI QSIDEYDGLN TVMNVLLQLV KHDDHHKRAV TASRLANFFA
NSTVDYSRYN QDIIRALLIS FDDRDKEVVK AAWTALNEFT KRLKKEEMEA LVQSTRQTLL
QVGVPGSNLP GFELPKGINA ILPIFLQGLM NGTAEQRTSA ALAISDIVDR TSEASLKPFV
TQITGPLIRV VSERSTDVKA AILLTLNNLL EKMPTALKPF LPQLQRTFAR ALADTSSELL
RSRAAKALGT LIKFTPRVDP LIAELVTGSK TSDSGVRTAM LKALYEVISK AGSNMGESSR
TAVLGLIDMD TDTTDSTMTI TNAKLLGALI KNVPPEIAHG LLKNRVVTTH FTNASVLALN
AVLVESPQTL LESPLADDLP DLLCQGMSNK NLFVADNSIL ATGKYLLTDS PKSFESIKPI
FSTLATIISP GNPSDSRRLA LVIVRTVSRA NLEMVRPHLP LLAPPVFASV RDPVIPVKLA
AEAAFIELFS VVDEETKVFE KYMAGPGADL PANTKRSMQD YFKRVAVRLG SQARERREAE
GGQGGLGLAN DEVEDEKEIW SVGSVEIGGG VFSQD
//
