ID A0A1Y2VUN8_9PEZI Unreviewed; 1004 AA.
AC A0A1Y2VUN8;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OTB00621.1};
GN ORFNames=M426DRAFT_65524 {ECO:0000313|EMBL:OTB00621.1};
OS Hypoxylon sp. CI-4A.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001833 {ECO:0000313|EMBL:OTB00621.1, ECO:0000313|Proteomes:UP000242955};
RN [1] {ECO:0000313|EMBL:OTB00621.1, ECO:0000313|Proteomes:UP000242955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CI-4A {ECO:0000313|EMBL:OTB00621.1,
RC ECO:0000313|Proteomes:UP000242955};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
CC -!- FUNCTION: Component of the coat protein complex II (COPII) which
CC promotes the formation of transport vesicles from the endoplasmic
CC reticulum (ER). The coat has two main functions, the physical
CC deformation of the endoplasmic reticulum membrane into vesicles and the
CC selection of cargo molecules. {ECO:0000256|ARBA:ARBA00025471}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004255}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
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DR EMBL; KZ111595; OTB00621.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2VUN8; -.
DR STRING; 1001833.A0A1Y2VUN8; -.
DR InParanoid; A0A1Y2VUN8; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000242955; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF4; SECRETORY 24CD, ISOFORM C; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000242955};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 299..337
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 377..624
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 631..715
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 727..830
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 858..902
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..72
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1004 AA; 109244 MW; F512FF96BC7D1A47 CRC64;
MADYSMYHSL GQGEQLDPND PNRTTQPAPQ QFQPPIATNP YQQNPAYGSP VPGQQYYGNP
PPGGPSPVAP GFAPPQDGGL ASQMAGMSIR DGQASVRKNK KKDRHVFHSV EAPAGSSQPY
NGIPPVGTPA TAFLNADPST QIGGQFIGQP VSPNQFPAAV NAPYQPGTPA TAAEFAARGG
QLDSGQSPTF VPAAGGGQVS PDDIPSVPVS RDVPQQYYLT NQYPTFERHV PPPATVSFVA
WDQGNSSPKF TRLTMNSIPA NAEGLKSTGL PLGLVLQPLA GLQPGEMEVP VLDFGDVGPP
RCHRCRAYIN PFMMFRSGGS KFVCNLCTYP NDTPSEYFCA TTPQGVRVDR DQRPELTRGT
VEFTVPKEYW TKEPTGLHWL FAIDVTQESY NKGFLEAFCE GILAALYAPE DGEETDENGE
LKRRIPPGAK VGFVTYDKDI HFYNCNPALE QAQMMIMPDI EDPFVPLSDG LFVDPYESKA
VITSLLARLP TLFSDIKNPE PALLPTLTSC LAALEKTGGK VIASLSALPT WGPGRLFMRD
DGKYSSGEMD KKLFSTEHPA WRKTAEKMVA AGVGVDFFLA APSGGYLDIA TVGHISATTG
GETFYYPNFV AGRDNAKLSL EIKHTVTRET GYQALMKVRC SNGLQISGYH GNFIQHTFGA
DLEIGVIDAD KAVGVTFGYD GKLDSKLDAH FQSALLYTTA SGERRVRCCN VIASVSDNPR
ECMKFVDQDA VYTIIAKDAA SKLASTSSTL KDIRLGLTEK TIDILAGYRK NFSSQSHPPG
QLVMPEKLKE FAMYMLGLIK SRAFKGGNET SDRRVHEMRM IRSIGAPELS LYLYPRMIPI
HNLNPEDGFA DAQTGQLKVP PAIRASFSRV EPGGVYLVDN GQQCLLWFHS QTSPNLLVDL
FGEGKDSLNS LDPYSSSLPV LQTHLNAQVR NILEFLKTVR GSKALTIQLA RQGIDGAEYE
FARMLIEDRN NEAQSYVDWL VHIHKGVQLE VSSPPVLFAL AVTS
//
