ID A0A1Y2VVI1_9PEZI Unreviewed; 959 AA.
AC A0A1Y2VVI1;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Coatomer subunit beta {ECO:0000256|PIRNR:PIRNR005727};
DE AltName: Full=Beta-coat protein {ECO:0000256|PIRNR:PIRNR005727};
GN ORFNames=M426DRAFT_323290 {ECO:0000313|EMBL:OTB01663.1};
OS Hypoxylon sp. CI-4A.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001833 {ECO:0000313|EMBL:OTB01663.1, ECO:0000313|Proteomes:UP000242955};
RN [1] {ECO:0000313|EMBL:OTB01663.1, ECO:0000313|Proteomes:UP000242955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CI-4A {ECO:0000313|EMBL:OTB01663.1,
RC ECO:0000313|Proteomes:UP000242955};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005727}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR005727};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane
CC protein {ECO:0000256|PIRNR:PIRNR005727}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR005727}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KZ111579; OTB01663.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2VVI1; -.
DR STRING; 1001833.A0A1Y2VVI1; -.
DR InParanoid; A0A1Y2VVI1; -.
DR OrthoDB; 151169at2759; -.
DR Proteomes; UP000242955; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR011710; Coatomer_bsu_C.
DR InterPro; IPR016460; COPB1.
DR InterPro; IPR029446; COPB1_appendage_platform_dom.
DR PANTHER; PTHR10635; COATOMER SUBUNIT BETA; 1.
DR PANTHER; PTHR10635:SF0; COATOMER SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF07718; Coatamer_beta_C; 1.
DR Pfam; PF14806; Coatomer_b_Cpla; 1.
DR PIRSF; PIRSF005727; Coatomer_beta_subunit; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005727};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR005727};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005727};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Reference proteome {ECO:0000313|Proteomes:UP000242955};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005727}.
FT DOMAIN 24..490
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 680..816
FT /note="Coatomer beta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07718"
FT DOMAIN 821..947
FT /note="Coatomer beta subunit appendage platform"
FT /evidence="ECO:0000259|Pfam:PF14806"
FT REGION 498..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 106701 MW; 5A58C4C5C0AEFA81 CRC64;
MSTFLENAYS LVHQDNTADV PSMSDLRMQL EKGTDETKVD TMKRILTVML NGDPMPQLLM
HIIRFVMPSR YKPLKKLLYF YYEICPKLDS TGKLKQEMIL VCNGIRNDLQ HPNEYIRGNT
LRFLCKLREP ELIEPLLSSA RACLEHRHAY VRKNAVFAVA SIFQHSPSLI PDASELIATF
LEGESDATCK RNAFAALASI DHDKALVFLS SVFEGIPNAE ELLQLVELEF IRKDAIQNSQ
HKARYLRLIF DLLEAPTSTV VYEAASSLTA LTNNPVAVKA AAAKFIELSI KEADNNVKLI
VLDRVDQLRQ KNEGVLDDLV MEILRALSSP DIDVRRKALT IALEMVSSKN VEEVILLLKK
ELSKTVDQEY EKNAEYRQLL IHSIHQCAIK FSEVAASVVD LLMDFIADFS NTSAVDVISF
VKEVVEKFPK LRPSIVARLV DTLSEVRAGK VYRGIIWIIG EYSLEESDIR DAWKRIRASL
GEIPILASEQ RLLDNVDGDE EKEKEQVNGH SKPAAPSGSR RVLADGTYAT ETALTSSSAA
AAKLEAVKAA QKPPLRQLIL EGDYYLAAVL SATLTKLVMR HSEISSDTAR TNALKAEAML
IMISIIRVGQ SQFVKAPIDE DSVDRIMSCV RSLAEFSQRK ELESVFLDDT RKAFRAMVQV
EEKKRAAKAA FEKAKTAIQV DDVVQIRQLS KKNVGDGTDE IELDLEKATG GESVSEDLSS
KLSRVVQLTG FSDPVYAEAY VKVHQFDIVL DVLLVNQTTE TLQNLSVEFA TLGDLKVVER
PTTQNLGPHD FHNVQCTIKV SSTDTGVIFG NVVYDGAHST DTNVVILNDL HVDIMDYIQP
ATCTETQFRT MWTEFEWENK VNINSKAKSL RDFLEQLMAC TNMNCLTPEA SMKGDCQFLS
ANLYARSVFG EDALANLSIE QDGEDGPITG FVRIRSRSQG LALSLGSLKG LNKIGTAAA
//
