ID A0A1Y2W192_9PEZI Unreviewed; 1005 AA.
AC A0A1Y2W192;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 13-SEP-2023, entry version 24.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M426DRAFT_12621 {ECO:0000313|EMBL:OTB03475.1};
OS Hypoxylon sp. CI-4A.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001833 {ECO:0000313|EMBL:OTB03475.1, ECO:0000313|Proteomes:UP000242955};
RN [1] {ECO:0000313|EMBL:OTB03475.1, ECO:0000313|Proteomes:UP000242955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CI-4A {ECO:0000313|EMBL:OTB03475.1,
RC ECO:0000313|Proteomes:UP000242955};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
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DR EMBL; KZ111559; OTB03475.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2W192; -.
DR STRING; 1001833.A0A1Y2W192; -.
DR InParanoid; A0A1Y2W192; -.
DR OrthoDB; 23973at2759; -.
DR Proteomes; UP000242955; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00014; CH_SF; 1.
DR CDD; cd05992; PB1; 1.
DR CDD; cd13246; PH_Scd1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010481; Cdc24/Scd1_N.
DR InterPro; IPR033511; Cdc24/Scd1_PH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR Pfam; PF06395; CDC24; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS51745; PB1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000242955}.
FT DOMAIN 227..401
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 905..1000
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 581..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..701
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 110491 MW; 1FA9AA2EE6A9BCDB CRC64;
MAHAPALLRT NTAPVFPADN KYGSMTASTM SSLRTSQLSG STVLNSSNSS LTSMSASTGN
VVATANIINQ KADASRSLYQ ICIALKQRLA RVPNFETHLE ALEANRGDDG PVESLWNLLR
TGLPLLTIYN TLQPESQLEI DPTANDTKRS KLAIFKFVEA CMKQLKFPPS ESFVISDLMG
NDTTGFVKVT QVVNRVLDRA EQQGLLLQVD PYLEVVGPVA PGSQMSYRDH IIQELVDTER
KYVQDLENLH DLKKTLEQKG VIPGDIIHQI FLNINSILDF QRRFLIRVET ANSMTEEAQR
WGAPFAIYED AFDIYQPFIA NQRKAGQIAN QVFDKIQLAD HPVTYDFNTL DGFLLKPMQR
LVKYPLLLKS LLKKCENEEV RADLTAGIEA SERVLSKANE AVDRDLLDEA LEDLIRRVDD
WKNHRVDQFG RLLLHGVYTV ITGRSEQEKD YEIYLFECIL LCCKEVIPNK SKEKKDKNKT
GPRIPNKNNK LQLKGRIFMT NVTDVLSYAK PGSYTVQIWW KGDPGVENFI IKFSNEETMK
KWETGLVAQR KENAPNTAAT PDQTTPNFAW MQNQSNIENP YAQQEEDDEE EDEVQQPPQV
SPPNMGFGGN STGGVMARNA SDTSLRARSA TAGSTQSLAS IARAPPPRFP LPAPPGQLSL
QTQGNAQSPG PHAGESYFSP TAESPASSRT STASTMFGGQ FPFPRTGTPQ GGWEDSNRYT
APAMPRAPSR DGPSPMNGRN PRGPSLPVMA SSQSQTLTQQ QRSRSYSTPD INGQPNGRRT
NNSTPVPAVP GIPPHLHPAH DANIPRSQTG SPRQDVPIRA NTQSPGVQRD GRSTQQSGQY
GGTMAQFPTQ PVYSRQTTPA PATAAPTGSL PPPLNINNQQ PVSPALGTAT QHNPLASPDM
SIPAQLKVKV NCDNGAYITL VAPFNIAYQS LRDRIDAKLG RFTSSSIAKG NLKLRYRDED
GDSVTIESDD DIQIAFSEWR EGARNTSNGV GEIELFCVGE VGETG
//
