ID A0A1Y2W586_9PEZI Unreviewed; 1162 AA.
AC A0A1Y2W586;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Cell division control protein 25 {ECO:0008006|Google:ProtNLM};
GN ORFNames=M426DRAFT_73105 {ECO:0000313|EMBL:OTB04960.1};
OS Hypoxylon sp. CI-4A.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001833 {ECO:0000313|EMBL:OTB04960.1, ECO:0000313|Proteomes:UP000242955};
RN [1] {ECO:0000313|EMBL:OTB04960.1, ECO:0000313|Proteomes:UP000242955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CI-4A {ECO:0000313|EMBL:OTB04960.1,
RC ECO:0000313|Proteomes:UP000242955};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
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DR EMBL; KZ111546; OTB04960.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2W586; -.
DR STRING; 1001833.A0A1Y2W586; -.
DR InParanoid; A0A1Y2W586; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000242955; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd11883; SH3_Sdc25; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000242955};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..69
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 740..873
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 908..1145
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 150..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1162 AA; 130246 MW; 874A317084B848B4 CRC64;
MNGILGTAPQ GTLYVRALYD YEADDRTSLS FHEGDVIQVI TQLESGWWDG VINGVRGWFP
SNYCQIIENP EEIPEQMQND DGENGNGELD DPAMYDMELE DDMESDQDDF SGLPLEGART
SRKSGADFWI PQATPDGRLY YYNTMTGESS MELPLESPSF NETGPRDRMN VKMPEKSRVP
PEMMARGLTQ DEDEDSEATS ASELEGELLM KSSMSSLPSR RRGYGTDSVG VSPSPSMDSI
NGMSQGIRSR GETFINTNVA LGAGGVPTLA SATSFTGASF NLPQAATIPR SFFDDGTTQP
LSWNLLIANM KRAIDRYRDA ITSNNRSEYV ARAEDISDHL RLLLAAGSGT TDNHSGQPSI
ISTNKALYPH FRDMMSKFSK LVISSHIAAA DWPNAESIQK CMQEADGVLL GVFSFVEVAR
QQRGEEIPRL FPGFVIGSTT GGSWQNNGLG PRDPITSNFL EDEEIYLEPT AILDGKLLER
LDEYKRMLVS SIRELEKNLG ISDKVVSPYK HELVGNNVCI AGGKVLEMFK PWVAMIESID
LSSLGNTFQT PQLADFSTNK QSLYDNVSDL VLGCQAVAGP LGDEWAEVRG ESLEGRLDYV
RHCARALETN SSHVGFSLQL LSEQVQINLH QHHDARIRED NPPREQTRRD TMPSFDSIHG
RQGSRDLLGV RPPLMGSMSY TDGESASTTY RKAGDLSKVA RILGEGSIPQ GAMQQQVVEE
TPAFLRLDLE SDLSWDLKTN PPAVKGGSLL ALVEQLTRHD KSDFNFNNTF LLTYRSFTSA
RELFELLVKR FNIQPPEGLN NADYEIWRDR KQKLIRFRVV NIIKTWFENF WMEESNDETR
QLIRDIYSFA KDTVKSTETP GANNLMTVLD QRLNGKEAPK RMIQTFANNV PPPIMPKNMK
KLKFLDIDVT EFARQLTIIE SKLYGKIKPT ECLNKTWQKK VGENEPEPAP NVKALILHSN
QMTNWVAEMI LAQMDVKKRV IVIKHFVSVA DKCRGLNNFS TLTSIISALG TAPIARLKRT
WDQVPARTQT VLETMRRLMA STKNFGEYRE ALHAANPPCI PFFGVYLTDL TFIEDGIPSI
IKKTNLINFA KRAKTAEVIR DIQQYQASPY SLQPVPELQD YILSNMQAAG DVHEMYDKSL
TVEPREREDE KIVRYIKSTN LS
//
