ID A0A1Y2W9C4_9PEZI Unreviewed; 1134 AA.
AC A0A1Y2W9C4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DUF726 domain protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=M426DRAFT_10618 {ECO:0000313|EMBL:OTB05577.1};
OS Hypoxylon sp. CI-4A.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001833 {ECO:0000313|EMBL:OTB05577.1, ECO:0000313|Proteomes:UP000242955};
RN [1] {ECO:0000313|EMBL:OTB05577.1, ECO:0000313|Proteomes:UP000242955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CI-4A {ECO:0000313|EMBL:OTB05577.1,
RC ECO:0000313|Proteomes:UP000242955};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR EMBL; KZ111542; OTB05577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2W9C4; -.
DR InParanoid; A0A1Y2W9C4; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000242955; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242955};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 560..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 989..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..462
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1015..1037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1134 AA; 124703 MW; AD9D7990B3C5474C CRC64;
MASAGGAQEV DDFGLPIRKH IKPKGAEQDG NDNNKPTNGA EGNSSATAKD AKQLPENTNN
TTSAETTKPT DAALKPPEPP TKSARTSATN SDDEFEDAPS TPLPEPATPS KFEDIEEAKT
PMPTQSEFKK EPSPPKEQPK DGPDSYENLD LPQPSKRRGT LSKEAISGPS IKQVEASKHA
DEVQKLPRID HSRDTSLAST NHDVSEFSHQ QLTGHHDEKK ENEDEEWQAM PAYAPYDIYD
DDNRLVAKEH NPEEDENYGY GSLGGAGKGY TRVLDDEDAE SETSMDDNTR YLFKDPKSTS
MTEMDDEQRD AISQLQATKD LLTEGQRIAY VGVTRLELSE MVKEAESIEP LKKIKKDVQM
AAEAMKMWSQ KIMIRLYAHM DISPAEQVMI EQLAEHGVMP QDLTPVLMQN ARVKNPMAET
PSTPKLSLKS PRSSLSTSPG EGKPAEAPPP YDAHEGEGED MPEVKTPSQL PHTDKIDIDL
RWTVLCDLFL VLIADSIYDA RSRVLLERVG KDLEVPWMDI CRFEKRVTDA LEMQQEAERE
NWNEEEHLEN RRKLAQKRRY VMMGLATVGG GLVIGLSAGL LAPLIGAGLA AGFTTIGVGG
TSSFLAGAGG AAIITSGAAA SGSFMGGKAA NRRTGAVKTF EYRPLHNNKR VNLIVTISGW
MTSKADDVRL PYSTIDPVMG DIYSILWEPE MLTSMGDTIN ILATEALTQG LQQVLGSTIL
IGLMAALQLP VVLSKLTYLI DNPWAVSLDR AWAAGLILAD SLIDRNLGTR PITLVGYSLG
SRVIFACLLE LAKKGAYGLV QNVYIFGSPI VAKKEEFLKA RTVVAGRFVN GYNTTDWILG
YLFRLTNGGI RRVAGLAPID GVPGLENLNC TEFVVGHMEY RTAMPRLLRE CGWLVESDEF
GEIEDPDPDQ HREKQRELIN EIEEARKELE KEGSSKKSGW GIFGRKKKGS RQEWEVYEDS
HKGTDASSRT EDKEGNNHGI LFDVDAMRAE LAKEEEGQAK EIKSTLPPIK LDLTPPSASS
GNPRDSLRET RSAGGSFRGS SFDHRFSEER APTSLPPSRG LAFDLPPEDD IQMTFDTAFS
APLTMPPSPP EKDLSLARPE IKTAQTTPNL TLTDPWADDD EDFGKEKEIS MTFA
//
