ID A0A1Y2W9Y0_9PEZI Unreviewed; 894 AA.
AC A0A1Y2W9Y0;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OTB06573.1};
GN ORFNames=M426DRAFT_318964 {ECO:0000313|EMBL:OTB06573.1};
OS Hypoxylon sp. CI-4A.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX NCBI_TaxID=1001833 {ECO:0000313|EMBL:OTB06573.1, ECO:0000313|Proteomes:UP000242955};
RN [1] {ECO:0000313|EMBL:OTB06573.1, ECO:0000313|Proteomes:UP000242955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CI-4A {ECO:0000313|EMBL:OTB06573.1,
RC ECO:0000313|Proteomes:UP000242955};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; KZ111536; OTB06573.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y2W9Y0; -.
DR STRING; 1001833.A0A1Y2W9Y0; -.
DR InParanoid; A0A1Y2W9Y0; -.
DR OrthoDB; 67337at2759; -.
DR Proteomes; UP000242955; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF71; CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242955};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 176..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 333..421
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 520..705
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 768..892
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 100368 MW; 881B3346AB2A570F CRC64;
MPSEKSQYIP PPPIPSYDEA TRGNPSSSQP DWPPPRSPVD TRPDHETEAQ SLLSSRPRPD
PSRRAPNGYQ QPYVESDDEG SQWTLEDDDD SDDGEGARVR REMQELEVED PLDDSSSRSS
SSSWRKRIAS SLPQWKWRWR LPRLTVRLPR QNDTSNDEET ESSETRRFRW PTVNSAAAVL
LVGRLLAIFL ILGFLYLLFM SDLFTNMTRR IGGHMFDPEA VRQYVQGEIN SETMRNTLKH
FTSYAHIAGT EGDYALAMDV RNDFMKYGLE DVSVDEYYVY LNYPKAGGRT VQIISEDGKE
AKWTAALEEE DVGEEMTGRQ TFVFHGHSKS GNVRGPLIYA NYGSREDFKR LSDKGIDTKG
AIALVRYYGT QGDRALKVKA AELAGFAGCI IYSDPADDGF LKGEPAPNGR YMPADGVQRG
AVSLMSWVVG DVLTPGWESK KGLPRMDKDK TDGLVKIPSI PIAWRDAQVL LQHIQGFGDP
CPDEWHGGVP EVEWWSGNSS SPIVRLKNEQ DEEDKQEIWN VYAKIAGVEQ SEKSIIIGNH
RDAWAFGATD PNSGTAVMLE VARIFGDLLS RGWRPLRTIE FMSWDAEEYN LIGSTEFVEK
NLESLQKNAF AYINLDTAVS GQEFHAAASP VYRKLLYKVL DRVIDPNANA TLRALWDDRN
AELEGLGAGS DYVAFQDIAG TSSIDIRFDG AAHPYHSSYD NFDWMDRVGD PGFIYHNLLG
QVLGLLILEL ADRPIMPFDM GNYALALGRY LGNLWQWGEE KGTNKRYDLE PIKNAIGEVE
KAVVDFEKWE GSWEATVVAS NGWEPVGLGQ RRGDYNSRMA NFETGLLDLE LGGGIPNRTQ
FKHVVFGPQL WSGYDEAYFP AIRDAIEVEN WPLAQKIINK TADIISRAAK ALVD
//
