ID   A0A1Y2WHA5_9PEZI        Unreviewed;       617 AA.
AC   A0A1Y2WHA5;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE   AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN   ORFNames=M426DRAFT_317103 {ECO:0000313|EMBL:OTB08479.1};
OS   Hypoxylon sp. CI-4A.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Hypoxylaceae; Hypoxylon.
OX   NCBI_TaxID=1001833 {ECO:0000313|EMBL:OTB08479.1, ECO:0000313|Proteomes:UP000242955};
RN   [1] {ECO:0000313|EMBL:OTB08479.1, ECO:0000313|Proteomes:UP000242955}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CI-4A {ECO:0000313|EMBL:OTB08479.1,
RC   ECO:0000313|Proteomes:UP000242955};
RX   PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA   Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA   Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA   Henrissat B., Gladden J.M.;
RT   "Characterization of four endophytic fungi as potential consolidated
RT   bioprocessing hosts for conversion of lignocellulose into advanced
RT   biofuels.";
RL   Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR   EMBL; KZ111526; OTB08479.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y2WHA5; -.
DR   STRING; 1001833.A0A1Y2WHA5; -.
DR   InParanoid; A0A1Y2WHA5; -.
DR   OrthoDB; 869at2759; -.
DR   Proteomes; UP000242955; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR   PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000590};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242955}.
FT   DOMAIN          9..133
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          325..544
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          555..617
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   617 AA;  68222 MW;  019987699AAD6B5E CRC64;
     MEKVDTSERL AELRKLMSEN NVDVYIVPSE DSHASEYIAP SDARRAFISG FTGSAGCAVV
     TLDKAALATD GRYFNQASHQ LDNNWELLKQ GLLDVPTWQE WSADQAADGK VVAVDPTLLT
     SGAAKKLSDK IKKSGGKELA AVEDNLVDIV WGDSRPPLPN EPIIVLDEKF AGKDAKTKLI
     ELRKELDKKK SLGFVVSMLD EIAWLFNLRG NDIPYNPVFF SYAIVTASEA TLYVESSKLS
     AECQSYLQEN GVSIKPYKDI FVDASALRQS AQAEKTDESS DGRKFLISNK ASWALKRALG
     GDSMVEEIRS PIGDAKAVKN ETELEGMRAC HIRDGAALIE FFAWLEDQLI AKKATIDEVE
     AADKLESLRA KQKDFVGLSF PAISSTGPNA AVIHYKPERG SCSVVDPNAV YLCDSGAQYL
     DGTTDTTRTL HFGKPTEAEI EAYTLVLKGN IALDRAVFPK GTTGFALDGL ARQYLWQYGL
     DYRHGTGHGV GSYLNVHEGP IGIGTRVQYS EVSLSPGNVI SDEPGYYEDG AFGIRIENII
     MVKEAKTKYK FGDKPYLGFE HVTMVPYCRK LIDSSRLSPE EKTWLNDYNA DIWNKTKGYF
     EKDEVTTAWL KREIQPF
//