ID A0A1Y2WLL8_9PEZI Unreviewed; 4162 AA.
AC A0A1Y2WLL8;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=K445DRAFT_17279 {ECO:0000313|EMBL:OTB09796.1};
OS Daldinia sp. EC12.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Hypoxylaceae; Daldinia.
OX NCBI_TaxID=1001832 {ECO:0000313|EMBL:OTB09796.1, ECO:0000313|Proteomes:UP000243732};
RN [1] {ECO:0000313|EMBL:OTB09796.1, ECO:0000313|Proteomes:UP000243732}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC12 {ECO:0000313|EMBL:OTB09796.1,
RC ECO:0000313|Proteomes:UP000243732};
RX PubMed=28078400; DOI=10.1007/s00253-017-8091-1;
RA Wu W., Davis R.W., Tran-Gyamfi M.B., Kuo A., LaButti K., Mihaltcheva S.,
RA Hundley H., Chovatia M., Lindquist E., Barry K., Grigoriev I.V.,
RA Henrissat B., Gladden J.M.;
RT "Characterization of four endophytic fungi as potential consolidated
RT bioprocessing hosts for conversion of lignocellulose into advanced
RT biofuels.";
RL Appl. Microbiol. Biotechnol. 101:2603-2618(2017).
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DR EMBL; KZ112995; OTB09796.1; -; Genomic_DNA.
DR STRING; 1001832.A0A1Y2WLL8; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000243732; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 4.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 9.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000243732}.
FT DOMAIN 782..858
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2547..2623
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3613..3689
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4162 AA; 460259 MW; 99A7CB1C3050F0BC CRC64;
MIVSPTNAVF ASHSSLKNDI RVSVNPIPSP PSTDYALFLK SNRHERKVIF DLLIPELGSG
ISAAVRAYTA WTVLLASHGC TSELSIFAPG LGEFIGPLDT PLQWNSQVGD LTHQVKTKLK
DAFLGVVEAT SSDDASTSSE EKEGEYTFLI SITRDQLGPR EILLECHIHD DHICTRAVTH
GTPSDQALSL HLFRRQYEYI VRQICQPDGD EKPLVDLKAV SVQDLHNIWS WNARVPRGVE
DVCIHEAFME RARRHPDLLA VSAHDGELTY RELDDLSTRL AHLLIQHGLQ PHSTIIVFIE
KSKWVPLAQL AIMKAGCVST VLDASLPLQR QKAIAELVQP LAILTSPTCE DQAKALNLDC
PQFVLDQSSS QDWPPAHPKF LPTVSPSSWL YIVFTSGSTG TPKGAIISHA NYASAVATQQ
KGLDFREFDR VFDFASYAFD AAWCNFIHSI MIGGCLCIPS DEERKGDLAG ALRKYQVNYA
VLTPSVAWFP ASELPSSLRT IHFGGEPLKA ALVKELSTNS TVINAYGPAE CSTVSTAIVA
DPNDDSDPTI GTGLGACTWV TKLDGSDLVP IGEIGELWVE GPIIGQGYLR NPEVTARTFV
EDPEWLLRGC PSLAGIRGHT GRRGRLYRTG DLVRYRPDGN LEFVGRKDSQ VKIRGQRVEL
GEIEYNLNRA LTDEARAKNV QIIAEVIKPE GSDVSTLVSF LFMAVSSGVS PEETKPILSE
ALAGIEDRLS KFVPPYMIPS AFLPIEEVPM TPTGKVDRRR LRESGGKLYW QQLNAQPVAE
EEPASELEAK IRQVWSEVLN LPTRSIGLDS AFTRLGGDSI TAMQVVSRSR SQNISIKVAD
ILKLQTVRLL AQASKPVQEK VNLDSAQTDE SKAWSLTPIQ QIFFDNNPQG ENHYTLSFIV
KLVRHSTHQE LLEALLALTT RHSMLRARFR KRTEDSAWEQ YIAPAGPNSF LLEEHDFIDR
SSTEKVVQER QAGLDLVNGP VFSVDVFNSP NEAQTLLMSA HHVVMDLVSW RIIWHELSQY
LSGVTQLPRL ELSFQAWSRL QREEGEKLNP ATVLPFEITP ANFDYWGVKP GEVYFRDATL
NLSVVDAEAT ALLLGASNDS FRTEVLDILV GTLIYSFAQT FPDRRPPPVF LEGHGREPVA
GMDDFDLSEV VGWFTSIHPI ELGGGPENTI LDMIKFAKDV RSRVPGKGRP YFASRFYSEA
GRKAFESHKH VELIFNYRGS FQQLEDAKSI IKLEDRDDRN VFIPGDGANY QRPSLIDINL
VVQEGKLQIY TSSHKHMRNH ESVLRWADLY AETLTSVAHE LANLPARHTL ADFPLLDISY
DGLETLTAQL ESEGIKVTDV RDIYPCTPMQ EGIIISTNIG TASYHSVNIW QATSTGSEVS
ASRLKEAWEK VSRAHPVFST IFSTNPDTGR YVQIVLNHFN GAIIEQAADF ETAVEHLTKM
EGFKTSPSQP HCFFTICTGK DGDIACRLEM THALMDALSI PVIIGDLEKA YSGQTLSLRP
PFRNYVEHIQ STPAENRLAY WKQYLADVKS CNLPGDRALN RPKTERKGSY EWITLPTAVT
APISRICREK GLTRSAFLHL AWSLVLSHFT GMRQVLFGYI SSGRDTPIEE IEDIVGPLIN
MLIARVDLEQ SLPDIISAIN KYNIEHLENQ YVSLAEIQHE ISVKQLFNSN ITVREARGVS
SAADGSIQLD EISEEDPHEY DLVLAGTLNK GDTEVSFQYR TDFISLANAR AIQVALENAI
NFLGSVTEQD TSAAASYAKF NESFYDAYFY HTAGTDEAYA LEQWKAPYQG LEPGCHFPVL
PPTSLKPVAN ASTSHVIENL EWRDDYDVSA QILASWALLQ ASYGSSTDVV VGASSLGSEH
GATSGKIPAP IRTKVDLNQS VSSYLDSVQS TAETWAKLPS LAIHRLRELS EESALACDFQ
TVLSFSRAPA QNEGQYENAD SNAFRALFLD FAAVSSGIQI SARFDENVIS TEQVTRLLSQ
LEAVLRQIVS TAKSSSTLSE IDTITEKDLE KIAAWNATPL DEVYDLIHNL ISKTVQTMPD
APAISSWDGQ LTYRQLDKLS TRLAHRLVQL GVGPEVIVPF YFEKSMWVPV CVVAVMKAGG
AGVMIDSTQP IERASSIVSQ VNATLTLTSA TNVERAAKFE RVRLLVIDKA HMDSLPDPEP
GHSLPQEVKP SDLLYVSFTS GSTGKPKGAM ITHSNFAASI CNQQKALGFR AGQRVYDFAS
YAFDASWSNV LHSLTSGSCL CIPSEHQRSN ALLESIRDSK ATLLNATPSV LRHLDPKQLP
DIEQVLMGGE AWAEADFLDW IDNTKLINSY GPGECTIKSC LIRAFRGMVP NTIGVGIGLH
TWIVRTDGSE RLAPLGSVGE LWLEGPQVGR GYIGDETRTA ATFLTRPKWT DNSNTPHRFY
RTGDLVRYGA DGALVFVSRI DSQVKIRGQR TELGEVEHSL KRALHTGDLK AQVVADVFKP
LNGDNPILVA FLKAEEPNAW HKLAGVEERL AEMVPQYMIP TAYIALEEFP MTATGKIHRR
ALRATYEQKT LEQLVAQDVF RVTAHRAPRT PSEKFLQGLW ADILKIDPAT ISADDSFLRI
GGDSLGAMRL VSAARKRNVS LSVADIFRRP KLSALAELIE SQKPTLESTE SVIEPFSLID
GRISADEARS EAARLTGLEV ADIEDVFPST PLQAGLLAET VRRPGDNILT ETFNFRKDID
VDRFRTAWQN VVRAHPILRT RIIELPQQGL VQVIIRYENC GIEDGVPAEK FGLGTPLVNY
KITESSFSWS IHHSLYDGWS EPLIFDSLVK SYRSEPIEDA APFQAFIKYV QESNGAGAKE
FWENQFQNFN AQNFPILPSK TYKPRCDQRL EIDIKDIVSD DDYTAATKIR LAWAILLSTV
TNSADASFGA TVSGRQANVP GMENISGPTI ATVPLRVAID RSKTVEELLQ QVQLQAADMM
PFEQTGLQQI RRISENCDLA CQFQSLMVIQ TGRNQDAEDI LFESSYVEPE SEGLDPFRNY
AILLEVLLKP ESIFLRADYD SNVVSSSQFR RLADRFENIL RQISLPEVQD KPVSLLDTSS
LEDLKQIWSW NDTYLERAEK TIHEIFGEVA AKQPDAPAVC SWDGDFTYAE LDGVSTRIAY
EILRAGLPQT GQRIVPLFFE KSKWTSASQL AVMKANGTCV TLDASLPIAR LHTVMDLTSP
QVIVTSAEQE SRARDVAPPT ARIIVISDAS VATFEVAEDS SLPVVDPDTW LYVVFTSGST
GVPKGAIVSH ANFASAIKYG QEPLRYSPET RTYDFSSYAF DASWLNVLYT LCGGGCLCVP
SNYEIQNEPK EAVARRGANS ALMIPSVSRF MHGVDFKVIN FGGEKLGRDE IDYWKDHATL
LHSYGPSECT PIAIHTTLDP ARERIVIGKA LATRIWIVEP ERGTSLAAVG DIGELWIEGP
TVGQGYLNEP EKTKASFVED PQWLVQGCPG FPGHRGRLYR TGDLVRYEED GSVEYIGRKD
AQIKIRGQRV ELEEIEHHVH DAIGKNIASQ VIVDIIRPAG STEAALIAFI KLSKDGIVSG
TPEAYAYAQE LASSANRLLS ATVPGYMIPN GYMIVDTIPN TASGKVDRGK LREAALAMRK
EDLLRVDRIG RRAPETPNEV KLHAIVARVL SWSGESFGMD NNFIQLGGDS ISAMRLASIA
RDEGIPLTVA DILTKDRIAD LLVTNSEADL VNESEQSLFG LLDVPDLRAF IEEEVIPQVL
PGRGKLVDVL PTTDMQSAYL RDNLAVPRLS WFYSYIDFDH IADEQRLIQS IEKLVEFCDI
YRTAFIRSGD SFYQAIFDSW KPTVNIINDV NSADIALDKV IEEEISSPIS LGTPLIQFAL
IKETSGKSKL AFGRSHAVYD GISIGQTLKV LAEIYNDSTP EIKDFRQYVN HTQSNKANSY
PYWSKVLEKS SITTLPHSPT SLTEAGPPAV LKRTIPIPKA PSGITQASLF TLACATVLGR
LTGSQDVVFG RVVSGRASVP ASLQDVIGPC LNRIPVRVQF TPGQTKSEQL SALQKQYVES
ITHEITGLRD IVKNCTDWPE DTKDFGCWSQ YQNIDENPEL DLPGAKGGLG SPEMYHIPFA
ANFLEIFAIP SRDGTLTVRL IAGSGYEENI DTVRTLLWRV ILGPVTVRVF QINAAPGHRI
GGLRGSLYPS TNKIALFGEI ST
//
