ID A0A1Y3AXX3_EURMA Unreviewed; 690 AA.
AC A0A1Y3AXX3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Merlin-like protein {ECO:0000313|EMBL:OTF72644.1};
GN ORFNames=BLA29_001802 {ECO:0000313|EMBL:OTF72644.1};
OS Euroglyphus maynei (Mayne's house dust mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC Pyroglyphidae; Pyroglyphinae; Euroglyphus.
OX NCBI_TaxID=6958 {ECO:0000313|EMBL:OTF72644.1, ECO:0000313|Proteomes:UP000194236};
RN [1] {ECO:0000313|EMBL:OTF72644.1, ECO:0000313|Proteomes:UP000194236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Arlian Lab {ECO:0000313|EMBL:OTF72644.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:OTF72644.1};
RA Arlian L.G., Morgan M.S., Rider S.D.;
RT "Genome Survey of Euroglyphus maynei.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OTF72644.1}.
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DR EMBL; MUJZ01055288; OTF72644.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y3AXX3; -.
DR OrthoDB; 5476297at2759; -.
DR Proteomes; UP000194236; Unassembled WGS sequence.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR PANTHER; PTHR23281:SF39; MOESIN_EZRIN_RADIXIN HOMOLOG 2; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000194236}.
FT DOMAIN 2..324
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 473..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 319..402
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 610..648
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 690 AA; 79994 MW; 0654306427E9AA9C CRC64;
MIPVQVHTMD AQLEFEIDKN ATGRDLFDLV TRAIGLREVW YFGLQYVDSK GFISWLKMNK
RVCDQDIAIQ KRNNNNNKMK KSNTDSIMSF LFLAKFFPED VAEELIQEVT QHLFFLQVKQ
SILNMDIHCP AEVSVLLASY AVQAKYGDYT DTINGMGKLD VEELLPRGVL EQYQMTAQMW
QDKIRIWYED HKGMTRDEAE TEYLKIAQDL EMYGVNYFLI SNKKESELWL GVTALGLNVY
EKENKLSPRI TFSWSEIHNI SYDDKKFIIR PIEKSSSNLC IGNHDLFMRR RKPDSIELQQ
MKAQAKDERT RRQLERTRFL REKELREEAE KEKAALEQRL LQYQEEAHGV QEALRRSEET
AELLAEKARV AEEEAMLLSQ KAAEAEAEIQ RIKITAIKTE EEKHLIQRKA EEAELLATTL
AEETDRRTKE TEQLKEELYS TKLSTKQLLI LLNKFQHDNH ISQENLVPSA TITQLQQQQQ
QPPPPPTTPD PPSPHHHHHH HHHLHTTSNV LNNGCDIPGI ITHIYEDPND TIMKLNQYLA
NTNGVSSFYS NSLNDECCDN NNKLRNHSFT SNPSSSTNGS SSFNNKEWSS SEQSESHDFT
ATSMMNDFDM EKIESEVEKE RIEYLKKSKQ LQDQLKGLKS EIQVLKVEER LTSLDKIHEE
NVNKGESKYS TLKRTLSGTT KARVAFFEDL
//
