ID   A0A1Y3BEE8_EURMA        Unreviewed;       533 AA.
AC   A0A1Y3BEE8;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN   ORFNames=BLA29_001547 {ECO:0000313|EMBL:OTF79232.1};
OS   Euroglyphus maynei (Mayne's house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Pyroglyphinae; Euroglyphus.
OX   NCBI_TaxID=6958 {ECO:0000313|EMBL:OTF79232.1, ECO:0000313|Proteomes:UP000194236};
RN   [1] {ECO:0000313|EMBL:OTF79232.1, ECO:0000313|Proteomes:UP000194236}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:OTF79232.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OTF79232.1};
RA   Arlian L.G., Morgan M.S., Rider S.D.;
RT   "Genome Survey of Euroglyphus maynei.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OTF79232.1}.
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DR   EMBL; MUJZ01024144; OTF79232.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3BEE8; -.
DR   OrthoDB; 3093257at2759; -.
DR   Proteomes; UP000194236; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000194236}.
FT   DOMAIN          173..430
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   533 AA;  63412 MW;  04C974A7A14CEC42 CRC64;
     MINGQEQIIC TETMNRGNFL RKIERFGMDV QDTCLFPLAL PMDGSDIYRG HSTWESIHLL
     ADCVLMLWTT TTTTTKSSCQ SMNNVLGEPL RFLCFHPELM DRRKFPHVKS SSDGRKYDPL
     PFRRWCSELD LRDFPDNNKQ LMETEDPEMI LENFCRKSRT NCRQLAYKHE LKNPKCLAAR
     ITRLEKQNFL RITRREALNY LFGKIHSNNQ NLNQMIRFSQ ELSELVGCWI RTETSVEGRK
     QIMATIIEVA FILFMRNNFQ SFESIMRGLR LPSVYSLQES WRSLRLNNSI HFRIYHYLTT
     VIINQLQQKS FIFHSHSSLA TKTKSLPSLN TFFETLRLRS LPIICRLIDD NNNGGDHHID
     VRNIGHESLI DIINQYYHQC KDDNIRQKLN ELTINERRRR RKRNIMTKTN TGKRKKRFFQ
     FPKILRKEKH QQNEQQLVND ENVIIAASYM SLLTKKFDKS SINDAFHGRD DDCLQSLRMY
     IEQQFVDIRD QPLPDRWRII SVRNIDSNVH QLLTTQFFQL YKDLLEQIEQ YKF
//