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Database: UniProt
Entry: A0A1Y3BHM7_EURMA
LinkDB: A0A1Y3BHM7_EURMA
Original site: A0A1Y3BHM7_EURMA 
ID   A0A1Y3BHM7_EURMA        Unreviewed;       738 AA.
AC   A0A1Y3BHM7;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   13-SEP-2023, entry version 19.
DE   RecName: Full=Glutamine-dependent NAD(+) synthetase {ECO:0000256|ARBA:ARBA00017309, ECO:0000256|PIRNR:PIRNR006630};
DE            EC=6.3.5.1 {ECO:0000256|ARBA:ARBA00012743, ECO:0000256|PIRNR:PIRNR006630};
DE   AltName: Full=NAD(+) synthase [glutamine-hydrolyzing] {ECO:0000256|ARBA:ARBA00030681, ECO:0000256|PIRNR:PIRNR006630};
GN   ORFNames=BLA29_002034 {ECO:0000313|EMBL:OTF79096.1};
OS   Euroglyphus maynei (Mayne's house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Pyroglyphinae; Euroglyphus.
OX   NCBI_TaxID=6958 {ECO:0000313|EMBL:OTF79096.1, ECO:0000313|Proteomes:UP000194236};
RN   [1] {ECO:0000313|EMBL:OTF79096.1, ECO:0000313|Proteomes:UP000194236}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:OTF79096.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OTF79096.1};
RA   Arlian L.G., Morgan M.S., Rider S.D.;
RT   "Genome Survey of Euroglyphus maynei.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate +
CC         H(+) + L-glutamate + NAD(+); Xref=Rhea:RHEA:24384, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57540, ChEBI:CHEBI:58359,
CC         ChEBI:CHEBI:58437, ChEBI:CHEBI:456215; EC=6.3.5.1;
CC         Evidence={ECO:0000256|PIRNR:PIRNR006630};
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from
CC       deamido-NAD(+) (L-Gln route): step 1/1. {ECO:0000256|ARBA:ARBA00005188,
CC       ECO:0000256|PIRNR:PIRNR006630}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the NAD synthetase
CC       family. {ECO:0000256|ARBA:ARBA00007145, ECO:0000256|PIRNR:PIRNR006630}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OTF79096.1}.
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DR   EMBL; MUJZ01024882; OTF79096.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3BHM7; -.
DR   OrthoDB; 3030505at2759; -.
DR   UniPathway; UPA00253; UER00334.
DR   Proteomes; UP000194236; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004359; F:glutaminase activity; IEA:InterPro.
DR   GO; GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07570; GAT_Gln-NAD-synth; 1.
DR   CDD; cd00553; NAD_synthase; 1.
DR   Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   HAMAP; MF_02090; NadE_glutamine_dep; 1.
DR   InterPro; IPR003010; C-N_Hydrolase.
DR   InterPro; IPR036526; C-N_Hydrolase_sf.
DR   InterPro; IPR014445; Gln-dep_NAD_synthase.
DR   InterPro; IPR022310; NAD/GMP_synthase.
DR   InterPro; IPR003694; NAD_synthase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00552; nadE; 1.
DR   PANTHER; PTHR23090:SF9; GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE; 1.
DR   PANTHER; PTHR23090; NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE; 1.
DR   Pfam; PF00795; CN_hydrolase; 1.
DR   Pfam; PF02540; NAD_synthase; 1.
DR   PIRSF; PIRSF006630; NADS_GAT; 1.
DR   SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR   SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR   PROSITE; PS50263; CN_HYDROLASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR006630};
KW   Ligase {ECO:0000256|PIRNR:PIRNR006630};
KW   NAD {ECO:0000256|PIRNR:PIRNR006630};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR006630};
KW   Reference proteome {ECO:0000313|Proteomes:UP000194236}.
FT   DOMAIN          6..297
FT                   /note="CN hydrolase"
FT                   /evidence="ECO:0000259|PROSITE:PS50263"
SQ   SEQUENCE   738 AA;  84561 MW;  24A14B8ADD3BCA61 CRC64;
     MSSYKFGIAV CTLNQLCLDF KGNLSRILTS INRAIELGAS IRLGPELEIT GYGCEDAFYE
     IDTVFHSWQI FGEILKQNYR NIMICIGMPV IKDSCLYNCV TVIYNSKIVY IRAKNRLAIH
     GNYRENRYFK PWNDGTNGSI SWFELPPLIT EICGQKRVPF GDGAIIEIKD NVIDSSDLQA
     SLGVLRIGFE ICEELWHADT QSNRHFGLRA CHLVVNPSSS YWELRKLDNA YNHVRSVTSK
     TGGVYAYANN IGCDGGGRLC FYGRSFVIEN GNLLSMSNVS SHKLFDEVSV HLAIVDPINI
     QQFRMQNNIA IRSCSVAEKF IKFNDDKPYE DNSMLYSDIS DVNTISMENS KFFRNSIIGI
     HKTNISKNFV QLSPEEEIMR YCSLWLWDYL RRCIPGGIKG FIVPLSGGLD SSSVVCIVYS
     LCNFLYHQIY SIKNPDVIQS IKPIFDVETE LQPRDICQKL LRCCYLRTKF SGQDSYNRAK
     NLAELVGADF QTYDLTDIYQ TIIDTVPLGV KPKSTEDVTI QQQNVQARIR MVLTYYMSEC
     NRLVLATGNV DEALVGYLTK YDCSSADLNP IGSISKNDLK RFMIYSKQII PNSEQVLDHI
     INAVPSAELT GQDQKDEDDL GLTYDELSLF GRLRRGIYGT YGPYGMFCKI WNDRYSNHVR
     QVFNGELVEP KLLATKVKRF FTLYARNRHK QTILTPSLHT ETYSPDDNRF DHRQFLFNTQ
     WPWQFEQIDK MIEKILNK
//
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