ID   A0A1Y3BL86_EURMA        Unreviewed;      1846 AA.
AC   A0A1Y3BL86;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   08-NOV-2023, entry version 21.
DE   SubName: Full=Neurofibromin-like protein {ECO:0000313|EMBL:OTF80346.1};
DE   Flags: Fragment;
GN   ORFNames=BLA29_000586 {ECO:0000313|EMBL:OTF80346.1};
OS   Euroglyphus maynei (Mayne's house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Pyroglyphinae; Euroglyphus.
OX   NCBI_TaxID=6958 {ECO:0000313|EMBL:OTF80346.1, ECO:0000313|Proteomes:UP000194236};
RN   [1] {ECO:0000313|EMBL:OTF80346.1, ECO:0000313|Proteomes:UP000194236}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Arlian Lab {ECO:0000313|EMBL:OTF80346.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:OTF80346.1};
RA   Arlian L.G., Morgan M.S., Rider S.D.;
RT   "Genome Survey of Euroglyphus maynei.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OTF80346.1}.
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DR   EMBL; MUJZ01018670; OTF80346.1; -; Genomic_DNA.
DR   OrthoDB; 1356198at2759; -.
DR   Proteomes; UP000194236; Unassembled WGS sequence.
DR   CDD; cd13313; PH_NF1; 1.
DR   CDD; cd05130; RasGAP_Neurofibromin; 1.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF13716; CRAL_TRIO_2; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000194236}.
FT   DOMAIN          520..715
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          845..1003
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   REGION          70..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1742..1778
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..96
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:OTF80346.1"
FT   NON_TER         1846
FT                   /evidence="ECO:0000313|EMBL:OTF80346.1"
SQ   SEQUENCE   1846 AA;  209466 MW;  95C80F5A8C3B66AC CRC64;
     TYLLPNYHVY LELANASTIL TTGRAALQKR IMALLRKIEN CTQGCSQAWE DTFLNWDSTT
     KFLVSYPKSK LGDSEQSDSL HRNVSKRRAS HQSTEHELED QINEWANMTG FLCALGGVCF
     KKSASKSSSF AVNIIPDSNK KNLVLPNVHD SLQYCPVTQF VGVVLKLLVC HNEKFGTQIQ
     KHVKDLLAHE MSPMLYPILF DQIKILIEKF FDTNGQVIVT DTNTQFIEHI IFIMKSIFEN
     NAEHTTENLG QTTSIEHIML AIVRYVRHLD SNNNHHIHIK NKVCQLVEAM MARRDDLSFR
     QEMKFRNKLV EYLTDWVMGN SHQMQPTVYT DLTSLLRDLD QSCMQAVAAL LRGLPLQPEE
     SDRGDLMEAK SQLFLKYFSL FMNLLNECSE VLSTEDTVSN NSSEAARCTV AAARFQSSTS
     TKLSELRTYT IQAMSNLLSA NIDSGLMHSI GLGYHKDLQT RAAFMEVLTK ILQQGTEFDM
     LAETVLADRY EQLVQLVTMI GEKGELPIAM ALSTVVVTPQ MDELARVFVT LFDAKHMLSS
     LLWNMFYKEV EVSDCMTTLF RGSSLGSKIM AFCFKIYGSS YLKNLLEPLI KPLLDSATNN
     SYEVDSARFD DGDNVETNRN NLMALTQKIF NAIISSADKF PSQLKLMCHC LYQVLNKRFP
     NFPHNISAVG TVVFLRFINP AIVSPFELGI IEKQPAPKIK RGLMLVSKIL QNIANHVEFS
     KEQHMLCFND FLRTNFDAGK RWIYQIASEL EIIEYQSNHN ISFISDANVH ALHRLLWNHQ
     EKIGDYLSSS RDNKAMGRRP FDKMATLLAY LGPPEHKTIS ESQWNSMEMT STKFEEIMAK
     HNMHEKDEFK SIKSLNIFYH AGTSKAGNPV FYYIARRYKI GETNGDLLIY HVILTLKPFC
     HKPFELVIDF THTCADHRYR TEFLQKWFVV LPEIAYEKIV ATYIYNCNSW VREYSKYHDR
     LLMPLKGSRK LIFVESAQKL SEYIDIEQQR LPGATLSLEE DLKVFNNALK LSHKDTKVSI
     KVGPTAIQIT SAEKTKVLGI PVYLNDVYYA SEIEEVCLVD DNQFTLTIAN ESGPLSFIHN
     DCDSIVQAII HIRTRWELSQ PDSVTVHTKI RPKDVPGTLL NMALLNLGSA DPNLRTAAYN
     LLCALTGTFD LKIEGQLLET AGLCIPSNNT IFIKQISEKL AMNASHLTLE FLEECIQGFR
     SSNIELKHLC LEYMTPWLPN LTRFCKQTDD NKRQRVATIL DKLITLTIEE VEMYPSIQAK
     IWGNIGQISD LLDLTLDSFL KRSVTGGLGS SQAEIMADTA VALASSNVQL VAMKVISRLC
     RVIEKTCTSP TSTLEQHLMW DDIAILGRYL LMLSFNNCLD VANHLPYLFH IVTLLVHIGP
     ISLRASIHGL VINIIHSLCT CTKPSFSGET QRLLRLSLDE FSLPKFYLLF GISDVKSAAV
     TAFRTHPTLN YNRHYCTDRH YNNLTQDRAI AAMNENYDRL PLNSLETITD ALLEIMETCM
     KNIPGCDWLQ RWTEMSRSFA FRYNPALQPR SIIVLGCISK FTTDKEILGL LRILVKALES
     FQDLQLIESI IMCLTRLQPL LNPESRIHRA LFWIAISVLQ LDEISLYASG LALLEQNLHT
     LDSSSTFEMN TLKSVMMATR EPLEWHFKQL DHSVGLSFKS NFHCALVGHL IKGFRHPTPT
     TVSRTTRVLN MLLEIVAKPH KRDKFEVNLE SVPYLAALLP VSEEVQSRVH LRHRVSRMIL
     DRTSSKNYPT NELQTNPPTT HNNPTTQSTS TSSNINGANI NKLNITNISS SPATTMTVQT
     LAPSPLSSPS TLMNLPLSSY ITQPHKVMFS QTHTQYSYTN SSISSN
//