ID A0A1Y3G530_9PROT Unreviewed; 747 AA.
AC A0A1Y3G530;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=GTP pyrophosphokinase rsh {ECO:0000256|ARBA:ARBA00014315};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
GN ORFNames=HK11_09790 {ECO:0000313|EMBL:OUI89617.1};
OS Acetobacter sp. DmW_043.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acetobacter.
OX NCBI_TaxID=1670658 {ECO:0000313|EMBL:OUI89617.1, ECO:0000313|Proteomes:UP000196359};
RN [1] {ECO:0000313|EMBL:OUI89617.1, ECO:0000313|Proteomes:UP000196359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DmW_043 {ECO:0000313|EMBL:OUI89617.1,
RC ECO:0000313|Proteomes:UP000196359};
RA Ju J., Zhang J.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUI89617.1}.
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DR EMBL; JOMN01000003; OUI89617.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y3G530; -.
DR Proteomes; UP000196359; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:OUI89617.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000196359};
KW Transferase {ECO:0000313|EMBL:OUI89617.1}.
FT DOMAIN 52..151
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 395..460
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 673..747
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 747 AA; 82541 MW; 8243BBBB98254826 CRC64;
MSVKDAKPVT CDKLLSVVRG YAPDADLESI RRAFDVAQKA HEGQLRDNGD PYITHPLAVA
MILAGFRLDV SSVITALLHD TVEDTGVTQE QLRAEFGDTV SELVDGVTKL TRLELQSDRT
KQAENFRKLV LAMSKDIRVL LVKLADRLHN MRTLHFVERV DRRQRIARET LDIYAPLAER
IGMDRVKTEL QNLSFAQIEP EVDATLRARL NYLRGQGADV IEDVRRELLR LCHDAGLKNV
HVAGREKSPY SIWDKMQRRN VAFEQLSDIM AFRVIVDTRE DCYMALGAVH AAYSVIAGRF
KDYISTPKVN GYQSIHTGVT LRSPRNQKIE VQIRTAAMHD IAENGVAAHW AYKDGSGENT
EGSPGFRRPR WVQDLLEILE ASSAPDEFLE NTKLELYQDQ VFCFSPKGQL ISLPRGATPV
DFAYAVHSQI GDSCVGARVN GRLMPLRYEL QNGDQVEIMT ARGGAPSPSW ERFVVTGKAR
ARIRRYVAAQ QRQTYLDAGR SALAKAFRQE GVDGSEKILE PVLKTLKQNS LHDLYVAVGN
NSIGARDVVY ATYPELRRAV RAPRMVPGLP GVLGTAGPRL MAGTSGNQKK RADGNIPLVG
LGAGIAVHFA ACCHPLPGDR IVGVVATGRG VTVHTKVCQT LENFAATPER FLDVDWDYDA
MDRGGASTMR VGRISLIAEN VSSVLATVTN TVSKYDASIV NLKIVNRQLD FMEILVDVEV
RDLRHLSSVI GGLRAASGVT QADRARS
//
