ID A0A1Y3N0L9_PIRSE Unreviewed; 2225 AA.
AC A0A1Y3N0L9;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Adenylate cyclase {ECO:0000256|ARBA:ARBA00021420};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
DE AltName: Full=ATP pyrophosphate-lyase {ECO:0000256|ARBA:ARBA00032597};
DE AltName: Full=Adenylyl cyclase {ECO:0000256|ARBA:ARBA00032637};
GN ORFNames=PIROE2DRAFT_13090 {ECO:0000313|EMBL:OUM61017.1};
OS Piromyces sp. (strain E2).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC Neocallimastigaceae; Piromyces.
OX NCBI_TaxID=73868 {ECO:0000313|EMBL:OUM61017.1, ECO:0000313|Proteomes:UP000195826};
RN [1] {ECO:0000313|EMBL:OUM61017.1, ECO:0000313|Proteomes:UP000195826}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E2 {ECO:0000313|EMBL:OUM61017.1,
RC ECO:0000313|Proteomes:UP000195826};
RG DOE Joint Genome Institute;
RA Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays essential roles in regulation of cellular metabolism by
CC catalyzing the synthesis of a second messenger, cAMP.
CC {ECO:0000256|ARBA:ARBA00003896}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; KZ151003; OUM61017.1; -; Genomic_DNA.
DR STRING; 73868.A0A1Y3N0L9; -.
DR OMA; HPKSGCR; -.
DR Proteomes; UP000195826; Unassembled WGS sequence.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd17214; RA_CYR1_like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR036457; PPM-type-like_dom_sf.
DR InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF43; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00481; PP2C; 2.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00332; PP2Cc; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF81606; PP2C-like; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS51746; PPM_2; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000195826};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 355..445
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1257..1635
FT /note="PPM-type phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51746"
FT DOMAIN 1769..1958
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1312..1339
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2185..2212
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 15..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2225 AA; 251174 MW; 5806E40E7C089AEE CRC64;
MDPLGIGDTH LSKKKANNPI FSHTTGQSNP NTPPPRKQYY DGTGASSSNK YTMTMGNPNS
NANIQNGYDY NSGDMNQNYL PYGNMPISSN NPNNPNAYKS SGILGKNFLK PRHNGSPPTQ
IQSTSNHYPK KSVSSSKSSL NSSASNINSS ASSLYALMSV NTPNIQNQHF YASSPNLTSN
TVNSGSSSGI QQSKSIHDYG IFKKKERPKL PQEQETSGTT DVVDFSDFMS DPNHVPLECV
SLPALANQSS SQNLNRGDGL QQIYNPNMNQ TIMTSSWEPP DSWDVKIDEP LPMKDILQES
LGTQGHNDIN KFSNTNQELS VIHSGSIKDT ESFQTPEDIY YDNHYSNVKI EEDQKYNYIR
VFKTDLTFTT VMCYLNSNAD YVCKKVAAKF FINDYNKYNL VVIRNKLERI IKPNEYPLLM
QKRWLERLGY TSQDKLDLQG REDNSYCYRF IFKEIQIGRE ISPNHWKKPE VKDNPHINLA
GFGLTILPVY LFQNASEIIS LDLSRNLNIQ ELHSDLTPSL TSLKSLSLSH NRIHNFPRNV
HCITTLTHLN LSFNRIRTLE HTGIEHLRNL LVLELQCNLI EDIPESIAKG CQRLQYISLS
NNRIKSIPIS LFHNLRRVLR HIDISFNRLI GKLPPEIGEL EVLEILRLNG NRMDGDIPKR
LSECLQLREL DLRGNRFGSI VTYDQDGTEI LTETENYAQT MEVLSECKKL EILLLDGNPI
RWIGKMSAVE DVQHEMSTNI DPSKFIDFPV LKRFSMSYRI SIGNQKPMIF RITNLTGTLS
ELNISFCGLE ILPNNFFTKL TGIERLILDG NHLSELPNFS SSVRVHQKEI RQIGPFRMRH
LSIYYNRLMA LPDDIGELVE LEYLDVRSNN LKTLPDSIWQ CGKLRSINAT SNQLEQFPIP
INDENDTVSV NTAITDATLV ARRQRRMTTN ISIQAFPPLS FSLLALFLAD NRLTEDLCLA
LYFMPNLVVL NASYNDIADI TSWLDCAPPT PLVEQPYKSS RAQTPANWFS HLQELYLSGN
NIVTLPGEIE KLHNLSWLFL DNNKLSTIPG EVAKLKKLCA FDVGGQGGGR GEGSGLRYNI
NNWPYDWNWS WNLELKYLNL SGNKRLEITP NAHNQKLIPF DKDNKRLMGS MNKIDLPSRH
QAAGYNPYGN DLDQNQAMNI SISQRKSLSN FTTLTNLSML GLMDVTCLMV QIPDENDQRR
IRTTSSEIPQ TGIPGGIIKY GISDTLCRFA SEAARRESLY ISRDHSNNVR DSTYITNTAI
GVIPKEKYFL GIWDVVIPQF RNMDNESLFG IFDGRGTEDG TKLAEYLFRL FAGDFQAELK
KVEESLIKER NQMKGHSRNK EPIVLDSNSI KSAIRRTFLG LNKELGEKFR TSVSNKNHSD
YKNYNEDDDD ELFGCSAVIV YMVGDRKKEN CSLYVANVGD GTCILSKAGG NAQVISRSFK
VGNVMDWASS RVYDQNKVNS SSLSTYSMES HRTVQHSLNS SQGSLTGNVY TSSNSDSPKF
ISGLGDEMER IQNAGGWITS DGLVNGKTDV TRAFGYFNCL GSLNANPWIV KMELDFGDNN
QSGNVVHLTP ESDKHDDEAA DIKLKLGQNH SDEFLVLVNG AVLDAIRCGA DANNNETPGF
SLSTLDDTAQ VIVDIARSAL GNESSKRSKG TYQYQGIGKN TRSTTGWGSA ATKIRDVALS
HGAYGARTTI NANQKVKSSK GMMVMVLGLR DLVETAQRWM GARRGSTETG SDSLELMNLK
RRGSDVALKM KKGDMSIPPS IEPPTGQLAL VFTDIKNSTA LWETHAIAMR NSIKLHNLRM
RALLKQYGGY EVKTDGDSFM VSFVDLMSAI QWCLDVQTEL LKIDWPKEIL ESEDGEEVWW
DTINSEPVFN DEYLDDEDTD NDMDDDINED DEDIYQEKEE LPLETRIAMR KKNDIVLLFR
GLCVRMGIHY GTPLCEKDPT TGRMDYFGPM VNRASRICSA AQGGQIFISS EVIKEVTKRK
GGDLSQLRMS DTLDEKITDS MNIKTWIIGE KKLKGLETPE VLHVMYPKQY YLRHEYFTLM
QNRKQESGNN TGNLMDIRMN PIDINPMKEH RSSEPTTIDR NYVQTLGNLC LRLEFLAVNA
QNICFNNQNF DERIPVYPYL INSSSISIPL EATEKELTAA LEGIAIRIEN AVSILYLIQS
SPLNRILKTL GSYIDVNPNQ ILSALQEYVL AMKERDERLE RIRNERRERE RRIKNRASKA
ANTSI
//
