ID   A0A1Y3NFC6_PIRSE        Unreviewed;       369 AA.
AC   A0A1Y3NFC6;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Peptidase C14 caspase domain-containing protein {ECO:0000259|Pfam:PF00656};
GN   ORFNames=PIROE2DRAFT_40970 {ECO:0000313|EMBL:OUM66227.1};
OS   Piromyces sp. (strain E2).
OC   Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC   Chytridiomycota incertae sedis; Neocallimastigomycetes; Neocallimastigales;
OC   Neocallimastigaceae; Piromyces.
OX   NCBI_TaxID=73868 {ECO:0000313|EMBL:OUM66227.1, ECO:0000313|Proteomes:UP000195826};
RN   [1] {ECO:0000313|EMBL:OUM66227.1, ECO:0000313|Proteomes:UP000195826}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2 {ECO:0000313|EMBL:OUM66227.1,
RC   ECO:0000313|Proteomes:UP000195826};
RG   DOE Joint Genome Institute;
RA   Haitjema C.H., Gilmore S.P., Henske J.K., Solomon K.V., De Groot R.,
RA   Kuo A., Mondo S.J., Salamov A.A., Labutti K., Zhao Z., Chiniquy J.,
RA   Barry K., Brewer H.M., Purvine S.O., Wright A.T., Boxma B., Van Alen T.,
RA   Hackstein J.H., Baker S.E., Grigoriev I.V., O'Malley M.A.;
RT   "A Parts List for Fungal Cellulosomes Revealed by Comparative Genomics.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C14B family.
CC       {ECO:0000256|ARBA:ARBA00009005}.
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DR   EMBL; KZ150814; OUM66227.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3NFC6; -.
DR   OMA; MSHYLIK; -.
DR   Proteomes; UP000195826; Unassembled WGS sequence.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.12660; -; 2.
DR   InterPro; IPR029030; Caspase-like_dom_sf.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   PANTHER; PTHR48104:SF30; METACASPASE-1; 1.
DR   PANTHER; PTHR48104; METACASPASE-4; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   SUPFAM; SSF52129; Caspase-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022807};
KW   Protease {ECO:0000256|ARBA:ARBA00022807};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195826};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT   DOMAIN          71..358
FT                   /note="Peptidase C14 caspase"
FT                   /evidence="ECO:0000259|Pfam:PF00656"
SQ   SEQUENCE   369 AA;  42083 MW;  99A6545F033EFC32 CRC64;
     MVEFISKEKI KIKVVKKRII KKREIKNTIK TNINDHIHNQ IKKQEIWNKD TEKFYYDRDG
     DNFARSNCLG KKKAVYIGIN YLDSNNKLIG CVNDAINISE LFSRKFGFTE YILLTDDTND
     ERNKPTYDNI IKAMNWLVED AKAGDSLVFH FSGHGQSVVD KDGDEMDGFD ESILPSDYTK
     KGRIIDDDIY KILVEPLPKG CKLTAIFDCC HSGTIMDLPY TYQCPSHIEV IENDLRKAIF
     KKTNEVVNSI MEGNPEAISK SVKSILDGSI KRAVVNGTSP DTIRKLQCNG EVIQFSGCRD
     DQKSVDIKMG DIISGAMSHY LIKLLNKDRE YTYIELLSGI RQYLAGKKFS QIPQLSSTRP
     ISFKDKFIV
//