ID   A0A1Y3QEE9_9FIRM        Unreviewed;       870 AA.
AC   A0A1Y3QEE9;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   03-MAY-2023, entry version 17.
DE   RecName: Full=Penicillin-binding protein transpeptidase domain-containing protein {ECO:0000259|Pfam:PF00905};
GN   ORFNames=BAA04_00445 {ECO:0000313|EMBL:OUM95798.1};
OS   Firmicutes bacterium ZCTH02-B6.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1861639 {ECO:0000313|EMBL:OUM95798.1, ECO:0000313|Proteomes:UP000196077};
RN   [1] {ECO:0000313|Proteomes:UP000196077}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Nascimento L., Pereira R.V., Martins L.F., Quaggio R.B., Silva A.M.,
RA   Setubal J.C.;
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUM95798.1}.
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DR   EMBL; LZRQ01000183; OUM95798.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3QEE9; -.
DR   Proteomes; UP000196077; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001182; FtsW/RodA.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF01098; FTSW_RODA_SPOVE; 1.
DR   Pfam; PF00905; Transpeptidase; 2.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   4: Predicted;
KW   Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        97..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        355..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        388..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        430..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          575..646
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   DOMAIN          653..855
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   870 AA;  89947 MW;  771B0016C34BBC97 CRC64;
     MSPLSWRARI EARVVERSLL WAALLPCGAL IALSRWTDGG WSTSFGLSAG YAFLFAGLHI
     SLALVRPAAD GLVLPLVAML SGVSLAILSR LDPALAFRQL CWLAAGGVLL VVAAAVEPAR
     LPPRAAGWMA GATILMLAVT ALFGTAAGGA RSWLAFGPVR FQPVEAAKVV LVWCWARWLS
     PVPAVGRTLA VAGAAALALV AQRELGYPLL LLATAALMAY LAAGHRGVGR ALLTSATSAA
     ALGLGYAVVS AGDRPWFPHL RTRLIAWIDP WSDPFGAGFQ ALQGLFALAE GGLLGRGIGV
     GSPATIPAVH TDFVLAAIGE ELGFLGTAAV LAGLALLVAR ALWLAHRATG EPERLLAAGL
     GLVVGLQSLW MAAALVRALP LSGVGLPLVS YGGSAAVAHM AAAGLILGST ARWPVTSEGN
     GTSTPSSRRV CLTGWMLVAC AAAVLALFAY WQVVRVDLRT HPYNPRFVVQ GLASRGGILD
     RRGEALAETR PASGGVTRLL LGPVSLSHVV GYVDPRFGLA GVEAALHADL AGLQRGLADW
     WRDPLRRRPE GKDVWLTIDV RVQAAAERAL GRRRGAVVAL RPATGEVLAM VSYPAFTLEE
     LPRLLEGGTG EVDAPLLNRA TQGLYPPGST FKVLTMAAAI DAGLVGTQAE VEALQRALAA
     SSNEPFVHLG LQLGGRELAS AASLVGFGAR LLADLPQKVS PLPAATREGD LAQISIGQGE
     LVATPLQMAV VAAAIANGGV AMRPHLVREV RTRDGRLTRF ARVEPLGPPA FSPSAARAVT
     EGMVLAVEDG TARQAAVAGV RVAGKTGTAQ NPHGEPHAWF IGFAPAFRPE VAVAVVIEGG
     GSGGRVAAPV GRDVMLAALE ATFAAAEVNR
//