ID   A0A1Y3T953_9FIRM        Unreviewed;       667 AA.
AC   A0A1Y3T953;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=DNA-directed DNA polymerase family A palm domain-containing protein {ECO:0000259|SMART:SM00482};
GN   ORFNames=B5G27_13360 {ECO:0000313|EMBL:OUN33106.1};
OS   Lachnoclostridium sp. An76.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1965654 {ECO:0000313|EMBL:OUN33106.1, ECO:0000313|Proteomes:UP000199802};
RN   [1] {ECO:0000313|Proteomes:UP000199802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An76 {ECO:0000313|Proteomes:UP000199802};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUN33106.1}.
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DR   EMBL; NFHL01000009; OUN33106.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3T953; -.
DR   OrthoDB; 9764911at2; -.
DR   Proteomes; UP000199802; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   CDD; cd08642; DNA_pol_A_pol_I_A; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000199802}.
FT   DOMAIN          390..632
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   667 AA;  75453 MW;  4DECC7394BB6FF47 CRC64;
     MEIREMSIDL ETYSDIDITK CGAYKYAESD YFEILLFGVS VNGGPVKVYD LACGDTIPEE
     ILAALSDENI TKWAFNASFE RICLSNWLKR HCPEHFRGYS IPEDPASKYL DPSSWKCTMI
     WSAYMGLPLS LEGVGAVLKL QDQKLKEGKD LIRYFCKPCK PTKANGGRTR NLPQHDSEKW
     ILFKEYNRRD VEVEIAIKQK LARFPVPDFI WDEYHLDQEI NDHGIMIDPE FVSNAIAFDE
     RSKASLMSKM RDITGIDNPN SVQQIKKWLS DRGVEMESLG KKEVAKFVKD SIGNMDGNIT
     EALKLRLLLA KSSVRKYQAM QIVMCSDGRA HGMFQFYGAN RSGRWAGRLI QLQNLPQNHI
     PDLAEARALV RSGDYDTMNL LYNDIPDTLS QLIRTAFIPK PGCKFIVSDY SAIEARVLAH
     IAGEKWRSKV FAEGKDIYCA SASQMFGVPV EKHGINSHLR QKGKIAELAL GYGGSVGALK
     SMGALDNGLQ EEELQPLVNA WRQANPNIVH FWWDVDNAVK TTVRQRIKTE VRGIRFSYKS
     GMLFITLPSG RQLAYVKPRI GENRFGGESV TYEGIGATKK WERIESYGPK FVENIVQAIS
     RDLLCFAMRN LSFCQIVGHV HDEVIIECSP EVSVQSLCGI MSRSPDWMPG ILIRGDGYQC
     DFYQKDS
//