ID   A0A1Y3THP4_9FIRM        Unreviewed;       689 AA.
AC   A0A1Y3THP4;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:OUN36022.1};
GN   ORFNames=B5G27_02400 {ECO:0000313|EMBL:OUN36022.1};
OS   Lachnoclostridium sp. An76.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1965654 {ECO:0000313|EMBL:OUN36022.1, ECO:0000313|Proteomes:UP000199802};
RN   [1] {ECO:0000313|Proteomes:UP000199802}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An76 {ECO:0000313|Proteomes:UP000199802};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUN36022.1}.
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DR   EMBL; NFHL01000001; OUN36022.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3THP4; -.
DR   OrthoDB; 9804124at2; -.
DR   Proteomes; UP000199802; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199802};
KW   Transferase {ECO:0000313|EMBL:OUN36022.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          73..229
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          275..620
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          641..689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..667
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   689 AA;  76354 MW;  0E98F4FE2CAF4DF0 CRC64;
     MAGRKRKKSR FGFLTKKFPL RMQRKLVMLF MAVILAFVVL IGRITYINVT KGSKYTKAVL
     DQQIYDSRVI AFKRGDIVDR NGTKIATSER VYNVILDVKM LTDKEEYLEP TKEVLSECFG
     IDGSVVDGLV KEDPDSQYEI LAQGVDYETA QKFNEIDEDD EKYPNVVGVW LEDDYTRTYP
     YGSLASDVVG FTYAGNNGAI GIENAYNDVL NGTDGREYGY FDSESSVERT VKPAKNGNTV
     VSTIDVTLQN IVEQAILEFN QEHAGDGELG SKNTAVIIMN PNTGEILAEA SYPNFDLNEP
     RNWSQVYPEE AWAAKTQEVA EDYTEQGRTP GWDELSDEEK EAEVLNDLWR NFCVSDAYEP
     GSVAKPFTVA AGLETGTLTG NETYYCGGSK NVMGWEIGCH YRAGHGTETI QDAIANSCNV
     ALMDMASAIG VDNFTRYQHI FGFGEYTGID LPGEAYTAGL LYTAENMTDV DLASNSFGQN
     FNVTMTQMAA AFASLINGGY YYEPHVVKQI QDENGNVIET KDPVLLRKTI SSDTSKMLKT
     YLKATMDYGT GQRAQVEGYD IGAKTGTAEK LPRGNGKYLL SYMGYAPQEN PEVLVYVVID
     EARNDSAGDS SLVLGLSKKI MEEAFPYLGI TTIAESGENV KTEGQNFGDT EYTDYDEDYE
     DTYDNPDGAY IDENYSPDLD DWASGETAE
//