ID   A0A1Y3VEP2_9BACT        Unreviewed;       648 AA.
AC   A0A1Y3VEP2;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=Heparinase {ECO:0000313|EMBL:OUN59135.1};
GN   ORFNames=B5G16_05840 {ECO:0000313|EMBL:OUN59135.1};
OS   Alistipes sp. An66.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC   Alistipes.
OX   NCBI_TaxID=1965650 {ECO:0000313|EMBL:OUN59135.1, ECO:0000313|Proteomes:UP000195674};
RN   [1] {ECO:0000313|Proteomes:UP000195674}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An66 {ECO:0000313|Proteomes:UP000195674};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUN59135.1}.
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DR   EMBL; NFHT01000006; OUN59135.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3VEP2; -.
DR   OrthoDB; 7335480at2; -.
DR   Proteomes; UP000195674; Unassembled WGS sequence.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.70.98.70; -; 1.
DR   Gene3D; 1.50.10.100; Chondroitin AC/alginate lyase; 1.
DR   InterPro; IPR008929; Chondroitin_lyas.
DR   InterPro; IPR012480; Hepar_II_III.
DR   InterPro; IPR031680; Hepar_II_III_N.
DR   PANTHER; PTHR39210; HEPARIN-SULFATE LYASE; 1.
DR   PANTHER; PTHR39210:SF1; HEPARIN-SULFATE LYASE; 1.
DR   Pfam; PF07940; Hepar_II_III; 1.
DR   Pfam; PF16889; Hepar_II_III_N; 1.
DR   SUPFAM; SSF48230; Chondroitin AC/alginate lyase; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Periplasm {ECO:0000256|ARBA:ARBA00022764};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195674};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..648
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013073692"
FT   DOMAIN          30..376
FT                   /note="Heparin-sulfate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16889"
SQ   SEQUENCE   648 AA;  75279 MW;  4C60B17B12B42699 CRC64;
     MKTVKTFALL LPLLLAFTTR NAQARHAASA FDLLDLARPG LEEVARLHSA GDDAEAAEAL
     LEYFRLRRGI VCPGVVPDSA VISADEQRWA DEALDHRFFV HSGYQPSYFY GDDIDWQYWP
     VRDNELRWQL HRMKWWVPMG KAYRRSGDER YAAEWCAEYL DWIRKNPLTE YDESRIGDWT
     SADNVYFAWR PLEVSDRLEF QIHQFLYFLP ARAFDGEFLM QFLENYHRHA EHIMHHFSAS
     GNHLLFQAQR LLFAGAFFPE FRDAPRWRAT GIGILNREMA RQVYDDGMQY ELDPHYHLES
     INIFFKALRM MDANGYRGEF PAEYPATIER MIDVHLNCSY PDGSTPLFSD NRRQEKEHYL
     ACYREWAAVF PENGFIRCRA TEGREGTNPE YLSRAFRTSG FYVLRNGWDT QATVMILKAG
     PQGFWHCQPD NGTFEVWHRG RNFLPDSGCY VYGGDSAVLA QRNWFRQTRV HNTLTLDGRN
     LETTDSKCTR WETAGTTDIL TVENPSYEGL THRRTVWFVD RRFFVIEDVA AGEAAGRVDL
     HYNLAECDPE EELAAGRVAT RFEDGNNLLV QVFGAEKAEP QEGWVSHVYR SRNPRPAYAF
     SAEKRPGREV RFITVLLPAE RSAETIIKAE HRRGTIRVTV DGRKYVLK
//