ID   A0A1Y3XBA8_9FIRM        Unreviewed;       645 AA.
AC   A0A1Y3XBA8;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Bifunctional metallophosphatase/5'-nucleotidase {ECO:0000313|EMBL:OUN82824.1};
GN   ORFNames=B5G06_09300 {ECO:0000313|EMBL:OUN82824.1};
OS   Flavonifractor sp. An52.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Flavonifractor.
OX   NCBI_TaxID=1965642 {ECO:0000313|EMBL:OUN82824.1, ECO:0000313|Proteomes:UP000195424};
RN   [1] {ECO:0000313|Proteomes:UP000195424}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An52 {ECO:0000313|Proteomes:UP000195424};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC       {ECO:0000256|RuleBase:RU362119}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUN82824.1}.
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DR   EMBL; NFIB01000021; OUN82824.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3XBA8; -.
DR   Proteomes; UP000195424; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008252; F:nucleotidase activity; IEA:UniProt.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   CDD; cd00845; MPP_UshA_N_like; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.90.780.10; 5'-Nucleotidase, C-terminal domain; 1.
DR   InterPro; IPR008334; 5'-Nucleotdase_C.
DR   InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR   InterPro; IPR006146; 5'-Nucleotdase_CS.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR11575:SF48; 5' NUCLEOTIDASE, ECTO-LIKE; 1.
DR   PANTHER; PTHR11575; 5'-NUCLEOTIDASE-RELATED; 1.
DR   Pfam; PF02872; 5_nucleotid_C; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SUPFAM; SSF55816; 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   PROSITE; PS00786; 5_NUCLEOTIDASE_2; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|RuleBase:RU362119};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195424};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        600..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          37..266
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          362..513
FT                   /note="5'-Nucleotidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02872"
FT   COILED          201..228
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   645 AA;  70122 MW;  30A7988A1E06D394 CRC64;
     MVHHGLKRLF LTVLTLILLI FICPAWGAAE NSHDAVILFT HDTHDHFYPA PSEDGGEYGG
     YTRLATLLAL ERVKYPDAIT VDGGDFSMGT LFQTIYATQA PELKALGAMG YDVTTLGNHE
     FDYRASGLAQ MLETAAASGS QVPAIVQSNG TVLDGEGAEE LRAAMEAYGV QNHMILTRGG
     INYGIFGLMG EDADACAPMS GMEFEAVADA ARREVAALEE ELAQLEGPSV IVCLSHTGTD
     GGKGEDYELA KAVDGIDVII SGHTHSTLEE PIQVNDTLIV SCGEYTTNLG VLVLELDDAG
     TVTDYDYRLV PVDETVTANT EMERLAQSFQ PIIEEEYLSQ FGLTFDQVLA RSEFDFTPIS
     QFGKEHKEDT LGNLIADSYI YAVQQAEGED YVPVDFAVVA AGVIRESFSA GEITTSDVFN
     VASLGSGADG TPGYPLISVW ITGRELRDAF EVDASVTGLM PAAQIYGSGM TWTWNPYRII
     LNRVNDYAQV LPDGTTVPLE DDKLYRVVTG LYTGQMLGTV NDQSFGILTI TPKDAQGNPV
     TNFEDQIIYT PNGSELKEWY ALATYLQSMG TVDQRYAAPE GRKVEEASLN PVSLLKGLNL
     VGWIALVVCL VVLALIVFIV YRIATRGRRR RYGGQKGRGY HRYRG
//