ID A0A1Y3XZA2_9ACTN Unreviewed; 1135 AA.
AC A0A1Y3XZA2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=B5G02_05790 {ECO:0000313|EMBL:OUN88567.1};
OS [Collinsella] massiliensis.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae; Enorma.
OX NCBI_TaxID=1232426 {ECO:0000313|EMBL:OUN88567.1, ECO:0000313|Proteomes:UP000195781};
RN [1] {ECO:0000313|Proteomes:UP000195781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An5 {ECO:0000313|Proteomes:UP000195781};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUN88567.1}.
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DR EMBL; NFIE01000011; OUN88567.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y3XZA2; -.
DR OrthoDB; 291295at2; -.
DR Proteomes; UP000195781; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF3; NEUTRAL PROTEASE B; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000195781};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1103..1124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 774..946
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 524..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1135 AA; 119904 MW; D31079EF052F8F28 CRC64;
MKRCRNCKAK LDRHARVCPQ CGTPVRRMRL RHKLLIALAA FVLVVGGAVG ALFATGHGDL
IAGLPARLGL VPGSTQEGAS GPGGAPSGGD GSGQDADFLL LGSAFTDRTI VGEDDARAAV
ADAAPALGMD DPASELGECA ANEVLGNSYY RFAQQHDGIP VYGRSVVVSA DGAGAPLSLT
SNYAAVGDIE TEPAIDAASA EDAAMAEVDG ALWTLPEGLT IYSLYDTDPT TAWQVLVVTD
DGAHRCFVAS DTGKVVATET ALNTASGKGL DGKTYTFETT PNVGGGYAMV DEGRSITVFD
AEGDDRAEII SHIELMGERG TTLRFIPNPD KDEGGYVWSA DGSTRADVTN EGAVSSWYIT
HDDGSTERIL GSNYGYFDHL VTSDDNETWD NRAAVSAMDS VVNVYDYYNE VLGWKSYDGA
GGPVYVVADL PENNAFAWAP TGEFAHVAAG GSEYFSSRVV VGHEYTHAVV RATCNLSGDK
TEDADALNEA VSDLMGIAAT DMGDDGLANN SATWNLDEIS RNLEDPVKSK SPNRVDGTYW
WDENRSPEKD SEGNDQYDEH HNATVIGHAG YLMCAEGSEA ATVDGDALST EELAKLVFVS
FFTMPSDCTF NEFATIMQNV AETFASQGTL TEAQVERVES AFIGVGLYGY DRGIDLTRDA
TLTVLDVNGE PYDNFTVTLE AVVMRTPGDP VAFNESGDTM RTATSTEPLA LAFPTDGVYR
MTVTDTANPS RSEEFSVGVS PAGDDTCEIQ TNFGGVDQGS EQAEHTRVVT GEQDISLVLD
VSSSMSGSRI EQLRSAAQGF VDTAFEDATS QVRVGMVAYN HEVSVRVPLA VEPGSLESEI
ASLGASGSTN IELALQTARS QLETGTADRK IIVLMSDGEP TDGAQGDDLI AIADELKDSG
FKIYTVGVEQ GASGEALLRA MASEGCYYSV DADSLNAFFA QIATEISGVP YMYVRVECPV
EVTVSYNGET LSSAGEDPST LASFGSLAFE EVEGADDASA ASAEGADTIK ILRLREGVPY
TVEIEGTGTG TMDYTIAFVD EHGDYADFRT FGGIDVAEGT KVETVAEYAP ETLLEVDEDG
DGVVDAAYRA GVNEEAKPVD NGWAPLAVFG ACLVAFAAVV VLRARSLVRV AARRR
//
