ID   A0A1Y3Y907_9FIRM        Unreviewed;       463 AA.
AC   A0A1Y3Y907;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Glutamate synthase (NADPH), homotetrameric {ECO:0000313|EMBL:OUN90800.1};
GN   ORFNames=B5G00_14975 {ECO:0000313|EMBL:OUN90800.1};
OS   Blautia sp. An46.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=1965636 {ECO:0000313|EMBL:OUN90800.1, ECO:0000313|Proteomes:UP000196301};
RN   [1] {ECO:0000313|Proteomes:UP000196301}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An46 {ECO:0000313|Proteomes:UP000196301};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUN90800.1}.
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DR   EMBL; NFIF01000020; OUN90800.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y3Y907; -.
DR   OrthoDB; 9803192at2; -.
DR   Proteomes; UP000196301; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR006004; SudA-like.
DR   NCBIfam; TIGR01316; gltA; 1.
DR   PANTHER; PTHR43100; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   PANTHER; PTHR43100:SF1; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196301}.
FT   DOMAIN          18..128
FT                   /note="Dihydroprymidine dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF14691"
FT   DOMAIN          141..448
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   463 AA;  49730 MW;  75F164D2755A5C69 CRC64;
     MGNVLEKVPV REQDPKVRAT NFEEVCLGYN KEEAMEEAAR CLNCKNAKCI KGCPVSINIP
     AFVHEVKEGN FEEAYKVISQ SSALPAVCGR VCPQETQCEG VCIRGVKGEA VSIGKLERFV
     ADWAKENGIK PEAPAEKNGH KIAVIGSGPS GLTCAGDLAK LGYDVTIFEA LHQPGGVLVY
     GIPEFRLPKD KVVKEEVENV KSLGVKIETN VIIGKSTTID ELLEKGGFEA VFIGSGAGLP
     MFMGIPGEVS NGVFSANEYL TRSNLMKAFR EDYDTPIKTG KKVVVVGGGN VAMDAARTAL
     RLGAEVHIVY RRSEEELPAR REEVHHAKEE GVIFDLLTNP VEIIPDENGW VKAIKCVRME
     LGEPDASGRR RPVVIEGSEF TMEADTVIMS LGTSPNPLIS STTIGLDINR RKCIIADEEN
     GQTSKEGVFA GGDAVTGAAT VILAMGAGKA AAKGIDEFIK NRK
//