ID   A0A1Y4AD10_9BACT        Unreviewed;       441 AA.
AC   A0A1Y4AD10;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:OUO20285.1};
GN   ORFNames=B5F90_07355 {ECO:0000313|EMBL:OUO20285.1};
OS   Alistipes sp. An31A.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC   Alistipes.
OX   NCBI_TaxID=1965631 {ECO:0000313|EMBL:OUO20285.1, ECO:0000313|Proteomes:UP000196483};
RN   [1] {ECO:0000313|Proteomes:UP000196483}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An31A {ECO:0000313|Proteomes:UP000196483};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NhaD Na(+)/H(+) (TC 2.A.62) antiporter
CC       family. {ECO:0000256|ARBA:ARBA00025753}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUO20285.1}.
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DR   EMBL; NFIO01000007; OUO20285.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4AD10; -.
DR   OrthoDB; 9772058at2; -.
DR   Proteomes; UP000196483; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004680; Cit_transptr-like_dom.
DR   InterPro; IPR045016; NhaD-like.
DR   NCBIfam; NF038006; NhaD_1; 1.
DR   PANTHER; PTHR43269; SODIUM/PROTON ANTIPORTER 1-RELATED; 1.
DR   PANTHER; PTHR43269:SF2; SODIUM_PROTON ANTIPORTER 1-RELATED; 1.
DR   Pfam; PF03600; CitMHS; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|ARBA:ARBA00022449};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196483};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        23..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        60..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        134..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        247..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        380..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          9..366
FT                   /note="Citrate transporter-like"
FT                   /evidence="ECO:0000259|Pfam:PF03600"
SQ   SEQUENCE   441 AA;  47926 MW;  6BC9BC7F7AAEC936 CRC64;
     MILLFVIGYA FIALEHKIKV DKAAIALLMC GAIWSVFSLF GHDANIAHEL IDHLGDTCEI
     LIYLIGAMTI VDLIDSHGGF GVITDHITTH NKHKLLWLLA IITFFMSAAL DNMTTTIIMV
     MLLRRIIANR KERWLFASII VIAANSGGTW SPIGDVTTIM LWMRGNVTSQ ALMGSLFLPA
     LISTAIPTAI AGHYIARKKT SMMEPAAAEN SLPKGVGPRL SKFVLVVGIL SLLFVPVFKS
     ITHLPPYMGM MISLGVMWVL TEIIYDKKRG IEESIKNRVS KVLKHIDMPT ILFFLGILMS
     VSALQSAGIL TEVAQFLDKN IHEVFTITGI IGLLSSVIDN VPLVAACMGM YPIADAATVA
     SSIDPAYMQS FLQDGVFWHL LAYCAGVGGS ILIIGSAAGV VAMGLEKITF SWYLKRITSL
     ALIGYVSGII VILLEHLLIG L
//