ID A0A1Y4AG85_9ACTN Unreviewed; 1030 AA.
AC A0A1Y4AG85;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:OUO18690.1};
GN ORFNames=B5F89_09395 {ECO:0000313|EMBL:OUO18690.1};
OS Collinsella sp. An307.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae; Collinsella.
OX NCBI_TaxID=1965630 {ECO:0000313|EMBL:OUO18690.1, ECO:0000313|Proteomes:UP000196349};
RN [1] {ECO:0000313|Proteomes:UP000196349}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An307 {ECO:0000313|Proteomes:UP000196349};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO18690.1}.
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DR EMBL; NFIP01000012; OUO18690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4AG85; -.
DR OrthoDB; 4638917at2; -.
DR Proteomes; UP000196349; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR045276; YbiO_bact.
DR PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000196349};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 331..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 736..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..799
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 782..821
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 822..887
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
SQ SEQUENCE 1030 AA; 112034 MW; EB4ABAAF3144B674 CRC64;
MSKGLTVRIG VLIAVVLASM VAMGVLLTGM QGQLTRSSYA EEIEYEEASL PELLEQADAE
TVENTAQFDA IYQSKAASVA FMAQNDAGFE ATDAKMAEYR ELLAVDNVMV VTRTGEIVAR
ATDTPADFTR MRFNRLRDTF DTNEPSEAVE IEYPEEEWLD RYYAARIDDE TMVVIEQNPA
ELRDLVESTG SLASVLGSIS LGQDGYVFAV SAKDYVIEYH PDEGLVGADA IDAGLSVENL
EDGTLANMTL DGEALFCGVT KIGDMYYISA VPEADMAASS AITVGVILFA FFVVIAAVTL
YGIFVLRDDE RRGHRDEDCR RVGPVRLNRA IAGRALVLAI VGFLGILVIS FYMQTLFALS
SQSLTLSERA ESIAESIERS QASAAELEDQ YGERYLSKAE VAAYIIDQNP ELATREKLGE
LADALQIQYI FTFNDQGVMT ATNSSYTNFV LSEDPADQSF EFRKLLQGVD HVVQDAMPDE
ISGELRQYIG VTTHDATGQL TGFVQLGIRP TRLENLLESV QIDHVLDGVQ VGADGFAFAV
SKVDGTIAYY PDQNTTGKDA AACGITENQL RDGFSDYITV NGDRYYASVA ETSDYYVFVV
AGEGALMNER GPLTIATGAI ALVCLIVVFA LISVAPSGRP AAPSATSDGD EDTGVVEVNI
GGRRVRSDSA VSRWLGRSFD WDGLSPERKV GCVLRWFAAV AVVVVCGAVI FKDSIFDKRS
LFAYILGGTW EHGLNIFAIT ASIMFACVLA TVAAALQKIL QFVSRVLDAR GVTMCRLISS
VVKYASVIGM LYWCLALIGV DTATLLASAG LLTFAVSLGA KDIVTDIISG LFIIFEGEFR
VGDIIQVGGQ RGTVMEIGVR TTKINDGSGN ILVLRNSSIS NVVNMTKEHS YAAIEVGIEY
GESLERVEAI LSRELPEMKK RLPAIIEGPF YKGVSMLADN SVNIKIVAEC AESDRGGLTS
DLLREMKLLF DVYDISIPYP QVVVNQPIEF KRATMADRIA AKEFNAEQRE ALKDLADEDE
DFDESNDSRR
//
