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Database: UniProt
Entry: A0A1Y4AH30_9ACTN
LinkDB: A0A1Y4AH30_9ACTN
Original site: A0A1Y4AH30_9ACTN 
ID   A0A1Y4AH30_9ACTN        Unreviewed;       342 AA.
AC   A0A1Y4AH30;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   11-DEC-2019, entry version 11.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=B5F89_02625 {ECO:0000313|EMBL:OUO21756.1};
OS   Collinsella sp. An307.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Coriobacteriaceae; Collinsella; unclassified Collinsella.
OX   NCBI_TaxID=1965630 {ECO:0000313|EMBL:OUO21756.1, ECO:0000313|Proteomes:UP000196349};
RN   [1] {ECO:0000313|EMBL:OUO21756.1, ECO:0000313|Proteomes:UP000196349}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An307 {ECO:0000313|EMBL:OUO21756.1,
RC   ECO:0000313|Proteomes:UP000196349};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUO21756.1}.
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DR   EMBL; NFIP01000002; OUO21756.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000196349; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361, ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN          34..333
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   342 AA;  38268 MW;  53AA5B722F00670C CRC64;
     MSMKFKRLLP IPKDIREEMP LSPEITAKKA AFDAEVARIF TGEDPRKVLI IGPCSADRED
     SVLDYMERLA AIAEEVREKI VIIPRVYTNK PRTKGTGYKG LLHNPDPEAP DDLLEGVKAI
     RRMHLRVIEE TGMFTADEML YPTNFQYLID LLSYVAVGAR SVENQEHRLV ASGVSVPVGM
     KNPTAGSTSV MLNSIYAAQA EQAFIYRNWE VETPGNPLTH AVLRGYIGLD GRTYPNYHYE
     HLERLAQNYT ADKYANPAVI VDCNHDNSGK RPLEQLRICK EVLDSCRRND AIRGLVKGFM
     VESYLEDGNQ AVDGGVWGKS ITDPCLGWAK TAQLILDLAD RA
//
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