ID A0A1Y4CPL6_9FIRM Unreviewed; 858 AA.
AC A0A1Y4CPL6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA polymerase I {ECO:0000256|RuleBase:RU004460};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU004460};
GN Name=polA {ECO:0000256|RuleBase:RU004460};
GN ORFNames=B5F80_01080 {ECO:0000313|EMBL:OUO48954.1};
OS Megasphaera sp. An286.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=1965622 {ECO:0000313|EMBL:OUO48954.1, ECO:0000313|Proteomes:UP000195529};
RN [1] {ECO:0000313|EMBL:OUO48954.1, ECO:0000313|Proteomes:UP000195529}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An286 {ECO:0000313|EMBL:OUO48954.1,
RC ECO:0000313|Proteomes:UP000195529};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU004460};
CC -!- SUBUNIT: Single-chain monomer with multiple functions.
CC {ECO:0000256|RuleBase:RU004460}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO48954.1}.
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DR EMBL; NFIY01000001; OUO48954.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4CPL6; -.
DR Proteomes; UP000195529; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR018320; DNA_polymerase_1.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR NCBIfam; TIGR00593; pola; 1.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU004460};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU004460};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU004460};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU004460};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004460};
KW Reference proteome {ECO:0000313|Proteomes:UP000195529};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT DOMAIN 1..262
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 615..822
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 858 AA; 95706 MW; 9A75DDAA1263636A CRC64;
MKETLLIIDG SSLLYRAFYA IPSLTDSQGR PTNAVYGFLN MLLKLYEQLE PHYVAVAFDK
DKHTFRNDLY DGYKATRKPA PDDLRPQFPL IREVLECLGI HVLELEGYEG DDIIGTVARQ
MEAKDFHIDI VTGDRDALQL VDENVTVHLT KKGITNMLAV TPDVMAAEYG YAPSQVVDMK
ALMGDTADNI PGVPGVGEKT AAKLIAQFQH VETLYDRIGE VKGKKLQEKL ADNKDKAFLS
KELATICCSV PVEYSLDMFL PQPRKEDVSA LFRSLGFKNM LSRFAAFDRF ASLADEEPAQ
DVSLQLLDDL QPQDLAGQVV AVEGVYESAA PLPVLKALAI AGRQGVFVVP AGREGEYLRA
LADAALVVTS QGKQLVKAAS PYTDKRLPLA DIILAAYLLD PTRTAYGLAY LSEKFAVPLQ
ESGDEALRLA GDAQFSFDVW PKAAEALEQA GLTTLYDTIE IPLIHTLAVM EMNGFTVDTE
RLMDMERELS LEADKLEEEI YDDAGETFNI NSTKQLGVIL FEKLGLPVIK KTKTGYSTDS
AVLEALMDQH PMIPKILQFR ALKKLISTYL DGLEPLISRE TGRIYTSFNQ MVTATGRLSS
SDPNLQNIPI RTEQGRKIRS LFVPGEGYDY IVSGDYSQIE LRLLAHLSQD PTMIDGFKKN
QDIHRRTASE VFGIPWDEVT PEQRSHAKAV NFGIIYGISD FGLARNISIS RQQAKEYIDS
YFARYSTIHA YMDKLVAEAR ETGMAKTMFG RIRTLTDINS KNFTRRSFAE RTAMNTPIQG
SAADIIKLAM NAVQDELERR SLRSRLLVQV HDELVLEVPA DEREEVETLL KDTMEHIVTL
SVPLVVDIHC GRNWEEAK
//