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Database: UniProt
Entry: A0A1Y4CW28_9ACTN
LinkDB: A0A1Y4CW28_9ACTN
Original site: A0A1Y4CW28_9ACTN 
ID   A0A1Y4CW28_9ACTN        Unreviewed;       342 AA.
AC   A0A1Y4CW28;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=B5F79_04070 {ECO:0000313|EMBL:OUO47521.1};
OS   Olsenella sp. An285.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Atopobiaceae; Olsenella.
OX   NCBI_TaxID=1965621 {ECO:0000313|EMBL:OUO47521.1};
RN   [1] {ECO:0000313|EMBL:OUO47521.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An285 {ECO:0000313|EMBL:OUO47521.1};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T.,
RA   Cizek A., Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OUO47521.1}.
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DR   EMBL; NFIZ01000004; OUO47521.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       31    334       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   342 AA;  38286 MW;  C8F4CE867B85DB5F CRC64;
     MAMKFKRLLP IPKDIRAEMP LSEEMAARKE AFDGSVADVL TGRDDRLLLI IGPCSADRED
     SVLDYACRLA RLAETVRDKI VVIPRVYTNK PRTKGTGYKG LLHNPNPEAA DDLLEGVKAI
     RRMHLRVVEE TGLFTADEML YPTNYQYLID VLAYIAVGAR SVENQEHRLV ASGVPMPVGM
     KNPTGGSTDV MLNSIYAAQQ RQTFIFRNWE VNTTGNPLAH AVLRGYVGLD GINYPNYHYE
     YLERLAEKYT SASFENPAAI IDCNHDNSGK RPFQQIRIIH EVLDSMSRSD TIRGLVRGFM
     VESYLVDGNQ PVGGGTYGQS ITDACIGWEK TERLVREIAE RA
//
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