ID   A0A1Y4D0T8_9BACT        Unreviewed;       650 AA.
AC   A0A1Y4D0T8;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE            EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN   ORFNames=B5F77_12470 {ECO:0000313|EMBL:OUO50588.1};
OS   Parabacteroides sp. An277.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=1965619 {ECO:0000313|EMBL:OUO50588.1, ECO:0000313|Proteomes:UP000196154};
RN   [1] {ECO:0000313|Proteomes:UP000196154}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An277 {ECO:0000313|Proteomes:UP000196154};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC       {ECO:0000256|ARBA:ARBA00006285}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUO50588.1}.
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DR   EMBL; NFJB01000034; OUO50588.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4D0T8; -.
DR   OrthoDB; 1032321at2; -.
DR   Proteomes; UP000196154; Unassembled WGS sequence.
DR   GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd06563; GH20_chitobiase-like; 1.
DR   Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR015883; Glyco_hydro_20_cat.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR029018; Hex-like_dom2.
DR   InterPro; IPR015882; HEX_bac_N.
DR   PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR   PANTHER; PTHR22600:SF21; BETA-HEXOSAMINIDASE A; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF00728; Glyco_hydro_20; 1.
DR   Pfam; PF02838; Glyco_hydro_20b; 1.
DR   PRINTS; PR00738; GLHYDRLASE20.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196154};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..650
FT                   /note="beta-N-acetylhexosaminidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012508813"
FT   DOMAIN          27..143
FT                   /note="Beta-hexosaminidase bacterial type N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02838"
FT   DOMAIN          146..478
FT                   /note="Glycoside hydrolase family 20 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00728"
FT   DOMAIN          538..636
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|Pfam:PF00754"
FT   ACT_SITE        317
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR625705-1"
SQ   SEQUENCE   650 AA;  74148 MW;  4C5BF2A4F941691C CRC64;
     MRNIIIGLFL FLFCLSACSP PVKEPVALIP LPDSVRIESG SFPLERLKTI QMPDEWEKVG
     EAFAEDLRKQ SDLSLSLSEN IGDIRAEHND EFPKEAYVLQ IRERQITIEA GDKAGVHHAL
     ATLQQLVLNA SEGKLPCLTV QDQPRFGYRG AMLDCSRHFR TVDELKECIR QLSFFKLNVL
     HLHLTDNQGW RLALDKYPDL AKKGSEYKDF PELSGKYYTK AELKELVAYA EARGVEIIPE
     VDLPGHSLAL LAGMPELSCR GGVFETYPEE RPYEKRKRMY ENMICIGNPQ CFAFVSDLVD
     ALVEIFPSPY IHLGGDEVST SVWETCPKCQ ALYRKEGMTD YHQLQDYFTK RVREIVRAKG
     KTMVGWDEIN TRGAASEEDL LTVWRNDGIE QQKKALASGI PIVMCPKDPC YFDFGYARNS
     TRKVYEWEPI AKDTPEEKRH LVKGGQGCLW TEFVVSQAEV ERMLYPRLCA LAEVLWSKPE
     KRDWVDFFQR LHIYNKVWEK LDIAYYPGDA LDEQWFLPAG DSIQLLQPAK VQTDMSAAWG
     GYNPEYVFDG DLNTFFSTSY APQKGNYLTL TLDEPKEVHA IRVVCDDSKE YLSEADLLIS
     ADGQHFRKVA SFTEDGKAEV KLKGESIQAV KIEVTAPHFS RLTIREIILE
//