ID A0A1Y4EPX4_9FIRM Unreviewed; 554 AA.
AC A0A1Y4EPX4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Hydrolase Nlp/P60 {ECO:0000313|EMBL:OUO72762.1};
GN ORFNames=B5F54_14160 {ECO:0000313|EMBL:OUO72762.1};
OS Anaeromassilibacillus sp. An250.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Anaeromassilibacillus.
OX NCBI_TaxID=1965604 {ECO:0000313|EMBL:OUO72762.1, ECO:0000313|Proteomes:UP000195568};
RN [1] {ECO:0000313|Proteomes:UP000195568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An250 {ECO:0000313|Proteomes:UP000195568};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C40 family.
CC {ECO:0000256|ARBA:ARBA00007074}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO72762.1}.
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DR EMBL; NFJK01000018; OUO72762.1; -; Genomic_DNA.
DR RefSeq; WP_015574144.1; NZ_NFJK01000018.1.
DR AlphaFoldDB; A0A1Y4EPX4; -.
DR OrthoDB; 9812962at2; -.
DR Proteomes; UP000195568; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR InterPro; IPR000064; NLP_P60_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR47053; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR PANTHER; PTHR47053:SF1; MUREIN DD-ENDOPEPTIDASE MEPH-RELATED; 1.
DR Pfam; PF00877; NLPC_P60; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS51935; NLPC_P60; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:OUO72762.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000195568};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 211..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 433..554
FT /note="NlpC/P60"
FT /evidence="ECO:0000259|PROSITE:PS51935"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 62074 MW; 3018E7FA2A9AC22A CRC64;
MSERTNKGGA TSGQKVPKSP KSKFRAKSQQ EQTAESKLRM EKRGEQLDKA KKKLAKQKPP
KKSGPVKKAG RAAGATVHGY VHGKLYEVEH ENVGTESAHR SELVGEAALR STSRYVKKQI
REHPAKAVQK AESRHIKATA DYQYRATVEA HPEMQKGGAV SRYIQKQKIK RQYAKQAREA
AKQTAKAAEK TAVTTEKLAA RAVAFVKRHP VGVLLFLACF LLLVLMQSCM SSAVTIGNGV
VGAIGASTYA AEDADLRGAE AAYCGLEAEL QDYLDSYEST HDYDEYHFEL DDIEHDPYVL
LSIISAIHEG AWTVDEVQGT LQMLFEKQYI LTETVVTERR YYLETDTWTD EEGNTHTDTY
RVYYDYYICT VTLENFNLSH LPIYIMGEDQ LSRYALYMSA LGNRPDLFPS SPYVAKYTAD
PVEHEIPEAY LADETFAAIL EEAEKYIGYP YVWGGYKPST SFDCSGFVSY VYNQCGWDFG
RLGAQGLYNI SRRTSSPRPG DLVFFTGTYD TPGVSHVGIY VGDGWMLHCG DPIGYANLNT
SYWQSHFYAY GRLS
//
