ID A0A1Y4F6G3_9FIRM Unreviewed; 742 AA.
AC A0A1Y4F6G3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Multidrug transporter {ECO:0000313|EMBL:OUO76320.1};
GN ORFNames=B5F54_01575 {ECO:0000313|EMBL:OUO76320.1};
OS Anaeromassilibacillus sp. An250.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Anaeromassilibacillus.
OX NCBI_TaxID=1965604 {ECO:0000313|EMBL:OUO76320.1, ECO:0000313|Proteomes:UP000195568};
RN [1] {ECO:0000313|Proteomes:UP000195568}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An250 {ECO:0000313|Proteomes:UP000195568};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO76320.1}.
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DR EMBL; NFJK01000001; OUO76320.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4F6G3; -.
DR OrthoDB; 9782006at2; -.
DR Proteomes; UP000195568; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000195568};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 154..348
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 439..714
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 721..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 82546 MW; 1E396323431CFCED CRC64;
MISTICHRRR LQLEKEKHTV HRFSNFVIRK RKWIEKIFAV AVVLSIIALC FVRVNYDLSK
YLPDDAASKA GLNVMDEEFG YPGTARVMVG DVSLYEAKLY KDRIEAVDGV NMVTWADTAA
DVYQSELFIN YEAIEDYYKD GYAVMDIIFD EDDSDAKTHN ALNEIEAITG DKGYFMGPAV
QNKSLDETLT REIAIAMVMG IFMISVILCL TTTSWFEPFL FLFIMGVAII INMGTNIFLG
EISFLTFSTA AILQLAIAMD YSVFLLHSFT RERQAGVEPE QAVANAIHSS VTSILSSGAT
TIVGFLVLML MRFKIGFDMG FVLAKGIVIS LLTVLLLMPA LLLRWGDKIE KTAHRSFMPS
FKGLGKAVFK IRYGVLILVA LLVVPAFTAQ NMNQFLFGNG SLGSSPGTKV YEDEQAINTR
FGRSNLVLAL VPNTNNVTER ALTESLRDLD YVKSVTSLAD TLPEGVPEDF LPESLTGQLH
SDDYSRIMIY LKTKDESAYA YQCTDEVRSI VESYYPEGSY LVGTTPSTQD IQTIITNDYN
YVNILSLLGV AVVVLLTFHS FIIPIVVMIP IEVAIFFNMA IPYLAGDKMI YMGYIIVSCL
QLGATVDYSI LTTNNYLEAR THLPKKEAAI HAISQSALSI LTSGSILTIV GYGLYYVSTV
SAIADMGHLV GRGALLSTLL VIFLLPVLLV LSDKLVMNQM RRRALRKAKR SIRWKTWLEK
HKRKKTTAPD TAQQNSKGGL LS
//
