ID A0A1Y4FA72_9FIRM Unreviewed; 877 AA.
AC A0A1Y4FA72;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=B5F53_04425 {ECO:0000313|EMBL:OUO80215.1};
OS Blautia sp. An249.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX NCBI_TaxID=1965603 {ECO:0000313|EMBL:OUO80215.1, ECO:0000313|Proteomes:UP000195974};
RN [1] {ECO:0000313|Proteomes:UP000195974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An249 {ECO:0000313|Proteomes:UP000195974};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO80215.1}.
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DR EMBL; NFJL01000003; OUO80215.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4FA72; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000195974; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000195974}.
FT DOMAIN 693..709
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 619..626
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 877 AA; 99568 MW; 6D0D4D7021C025D6 CRC64;
MALSPMMREY LKTKDEYRDC ILLYRLGDFY EMFFEDALTA SRELEITLTG KDCGLEERAP
MCGVPFHAVE NYINRLIEKG YKVAICEQVE DPKKAKGLVK REVVRVVTPG TTLDVMALDE
TKNNYLMSIV SVENGFGCAI ADITTGDCYL TELEKPQNLL DEINKFVPAE IICNDAFLMS
GIDAEDLRHR LKICIYTLDA WYFDDDRCRQ TLREHFQVGA LEGLGLGDYD SGVIAAGALF
QYLMETQKSA MTHMTSITPY LTEKFMLIDS SSRRNLELVE TLREKQKRGS LLWVLDKTKT
AMGARMLRSQ VEQPLIDKEE INRRLEAIEE LNDKAMLREE IREYLSPIYD LERLISRISY
QTANPRDMVS FSGSLAMLPH IRLLLKEFES PLLKEIYEDM DALEDVTDLI HRAIIEEPPL
SMRDGGIIKE GYHEDVDNYR ESKSNGKKWL SDLEARERER TGIKTLRIKF NRVFGYSLEV
TNSFKDLVPE EYVRKQTLTN AERYITQELK NLEDMILGAE DKLYALEYEL FCDVRKRVGD
QVLRIQKTAK AVAALDVLAS LSVVAQRNHY VRPSINQSGV LDIKEGRHPV VEQMIENDMF
ISNDTYLDNQ KQRVSIITGP NMAGKSTYMR QTALIVLMAQ IGSFVPAKKA NIGIVDRIFT
RVGASDDLAS GQSTFMVEMT EVANILRNAT NKSLLILDEI GRGTSTFDGL SIAWAVIEHI
SNTKLLGAKT LFATHYHELT ELEGKIPGVH NYCIAVKEKG DDIVFLRKIV KGGADKSYGI
QVAKLAGVPE TVLSRARELV EELSDADITA AVKDLTAPKK KTKITYDSVD MAQMSLFDTV
QDNDIIEEIK ELDVSNLTPM EALNILYQLQ NKIKNRW
//
