ID   A0A1Y4FA83_9FIRM        Unreviewed;       453 AA.
AC   A0A1Y4FA83;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN   ORFNames=B5F53_12815 {ECO:0000313|EMBL:OUO77720.1};
OS   Blautia sp. An249.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=1965603 {ECO:0000313|EMBL:OUO77720.1, ECO:0000313|Proteomes:UP000195974};
RN   [1] {ECO:0000313|Proteomes:UP000195974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An249 {ECO:0000313|Proteomes:UP000195974};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC       {ECO:0000256|ARBA:ARBA00005163}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUO77720.1}.
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DR   EMBL; NFJL01000013; OUO77720.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4FA83; -.
DR   OrthoDB; 9800864at2; -.
DR   UniPathway; UPA00223; -.
DR   Proteomes; UP000195974; Unassembled WGS sequence.
DR   GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06113; citrate_synt_like_1_2; 1.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000195974};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT   ACT_SITE        331
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        390
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   453 AA;  51382 MW;  A661BB6D52E901F1 CRC64;
     MSGFNMKVTP EIEKLTEICQ EKSKIDVDLY GKYDVKRGLR DLNGKGVLAG LTQISNVQAT
     KMVDGKEVPC AGSLSYRGYN IKDLTAGFLK DDRFGFEEVT YLLLFGALPN SQQLEEFHKL
     LINQQSLPRN FVRDVIMKAP SKDIMNALSR CVLTLYSYDK NPDDTSLPNV LRQCLNLISV
     FPMLSVYAYH AYNHYERGKS LYIHHPGKDL STAENILRML RPDKKYTPLE AKILDLALII
     HMEHGGGNNS TFTTHVVSSS GTDTYSAIAA ALGSLKGPKH GGANIKVVKM FQDLKKEVRD
     WEDEDEVRAY LERLLHKEAF DRKGLIYGMG HAIYSVSDPR AEVFKGFVEQ LAYEKGRKKD
     YRLYSMVERL APEVIAKERR IYKGVSANVD FYSGFVYSML DLPLELYTPM FAIARIVGWS
     AHRMEELINA DKIIRPAYKN VLGAAEYKPL NER
//