ID A0A1Y4FBP3_9FIRM Unreviewed; 630 AA.
AC A0A1Y4FBP3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=BlaR1 family beta-lactam sensor/signal transducer {ECO:0008006|Google:ProtNLM};
GN ORFNames=B5F53_00405 {ECO:0000313|EMBL:OUO81076.1};
OS Blautia sp. An249.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX NCBI_TaxID=1965603 {ECO:0000313|EMBL:OUO81076.1, ECO:0000313|Proteomes:UP000195974};
RN [1] {ECO:0000313|Proteomes:UP000195974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An249 {ECO:0000313|Proteomes:UP000195974};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M56 family.
CC {ECO:0000256|ARBA:ARBA00011075}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO81076.1}.
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DR EMBL; NFJL01000001; OUO81076.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4FBP3; -.
DR OrthoDB; 9762883at2; -.
DR Proteomes; UP000195974; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd07341; M56_BlaR1_MecR1_like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR008756; Peptidase_M56.
DR PANTHER; PTHR34978; POSSIBLE SENSOR-TRANSDUCER PROTEIN BLAR; 1.
DR PANTHER; PTHR34978:SF3; SLR0241 PROTEIN; 1.
DR Pfam; PF05569; Peptidase_M56; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000195974};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..343
FT /note="Peptidase M56"
FT /evidence="ECO:0000259|Pfam:PF05569"
FT DOMAIN 423..625
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 630 AA; 72388 MW; C419F0AEAD6FD6E9 CRC64;
MPWYVRTWRR KHSPRRSWKP SAAFSVTTGR KEGINLLPFV IHFLICNLFL CLCISLLSGI
KYLGRNLLSS RTQYRLWFPL FFLFLLPFLP LKREDFAWLW SWLPQKAAVS SAAFLPAGQT
SGRTPSAFFV NELPDFSVSI SRPVPSAICC LLLIVWILGI LFFSLSFFRS WLLLQRIRKS
ALLLQNENVR HICESCLSEL NIRRRIPVYS TAFLPSPVLA GFFRPRIYLP IRMISDFSAE
DMRFMFLHEL QHYRSNDILM SCLANAACIL YWFNPLVWYM QKTLRREREL ACDASVLELL
PECDYSAYGF TLLQVTESLQ KPSLFLAVPM GAAKKQLKQR ILQIASYRKS TRRQRTLGAF
ICLLALTFTV GISPVFASDA SEDRYSFEKA PETVTYLDLS REFEGYEGCF VLYDEGKDLW
QIYNQEAALT RTSPYSTYKI YDALLGLESG IITPEDSRMA WDGQSFPIDA WEADQDLNSA
IKNSVNWYFQ RIDEALGASQ VQDYLDEIGY GNQKMSRRLD LYWTDSSLKI SPAEQVELLQ
KLYHNDFHFS AENVNAVKQS LFLSSSSRGR LFGKTGTGQI DQKEVSGWFV GCLENQGNVS
YFATNIQADS DASGNRAKEL TERILSQIYD
//
