ID A0A1Y4FZA3_9ACTN Unreviewed; 323 AA.
AC A0A1Y4FZA3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:OUO88986.1};
GN ORFNames=B5F40_11590 {ECO:0000313|EMBL:OUO88986.1};
OS Gordonibacter sp. An230.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Gordonibacter.
OX NCBI_TaxID=1965592 {ECO:0000313|EMBL:OUO88986.1, ECO:0000313|Proteomes:UP000196177};
RN [1] {ECO:0000313|Proteomes:UP000196177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An230 {ECO:0000313|Proteomes:UP000196177};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO88986.1}.
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DR EMBL; NFJP01000023; OUO88986.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4FZA3; -.
DR OrthoDB; 9775207at2; -.
DR Proteomes; UP000196177; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30566:SF5; MECHANOSENSITIVE ION CHANNEL PROTEIN 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR30566; YNAI-RELATED MECHANOSENSITIVE ION CHANNEL; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..103
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 104..165
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT REGION 270..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 270..293
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 34194 MW; FF794382CC1CFE9F CRC64;
MEQLSRIIEG FARSDWIATA ITAVVILAAT AVCARIARRF MRRLLHFNEG KDLPSSSIFV
NIVRGAVWFL GVCIMLSTCF NVNVSAAITA LGIGGIAVSL GFQDTISNLI GGLQVSLMRI
VKPGDNIEVG SSSGVVKDVT WRHTSIRNSA GEEVIIPNSI INKTALVHLP PTNQVKLPIV
VVTDGERLDE VAAAIERSAA EAASTCSKLT KQPALTFTGI GDAGFQASLA FTVADSRTGS
RAGDAVLRAI APLTRAGGVP LAERVLDEAA HEATEREKGE GEQQHDVARS KPKAKSASRR
AGGRSNVRNR VAHALRAMKG EGR
//
