ID A0A1Y4G9B4_9ACTN Unreviewed; 625 AA.
AC A0A1Y4G9B4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Multidrug MFS transporter {ECO:0000313|EMBL:OUO92457.1};
GN ORFNames=B5F40_00730 {ECO:0000313|EMBL:OUO92457.1};
OS Gordonibacter sp. An230.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Gordonibacter.
OX NCBI_TaxID=1965592 {ECO:0000313|EMBL:OUO92457.1, ECO:0000313|Proteomes:UP000196177};
RN [1] {ECO:0000313|Proteomes:UP000196177}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An230 {ECO:0000313|Proteomes:UP000196177};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUO92457.1}.
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DR EMBL; NFJP01000001; OUO92457.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4G9B4; -.
DR OrthoDB; 9812221at2; -.
DR Proteomes; UP000196177; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR42718:SF47; DRUG EFFLUX PUMP JEFA; 1.
DR PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01036; TCRTETB.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..456
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 478..534
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 566..622
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 625 AA; 65075 MW; 23F146F1661DDCB8 CRC64;
MQGSSLVMLL SVLYGSAFLA GFNENLVNMA LMSIMGDFGV DSVTAQWLVT GYMIVATVVV
TCMAFLYRRF KLRTLFFVAA ALSIAGSVTG LFAGSFAVLL VARLVQAVGT GIFIPLMMNA
ILVVTPKNRL GSFMSIGGCM ITFGPAFAPV VCGALVTAFG WHSIFVVPVA AMAVLAVMGF
FFVKNLETSK AHLDVASVAL SAVVLTALSF GLSQLTIDPI AAAVALLATV VLTAAFVVRQ
LRCDHPLIDL APVKNRLFWP ALLLATVAMM STFSMSVLLP LYFEGAAGMT AFAAGLVMLV
PVLANAGATL VGGRIMDRRG EWPLLPLGFA GIAIGFFALA MVSPSLSVPV VFAAALLMYA
AVGFIFSPSQ TAGLRVLPPD QNPFGVALMT TFVQIAGCVG PSLYTGVMSS GQGSALARGA
SSASAAADGF ALAMTVAAVI AALGFALSFA YARAARARVR AKAAERAAAP RSVLAELMEA
DPYTLPASAS VGEAMRVFVE LKVGGLPLVD DAGRPAGFVS DGDVMRYLAD KHPVITGAYS
LMEAARGQTF DERLRELIAL PVGVIATERL VALDADATLE ETCALLATRR LKKVPVVREG
VIVGTVNRSD VLRYAMSACM AAASE
//
