ID   A0A1Y4HD63_9ACTN        Unreviewed;      1031 AA.
AC   A0A1Y4HD63;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Small-conductance mechanosensitive channel {ECO:0000313|EMBL:OUP05933.1};
GN   ORFNames=B5F33_10625 {ECO:0000313|EMBL:OUP05933.1};
OS   Collinsella sp. An2.
OC   Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC   Coriobacteriaceae; Collinsella.
OX   NCBI_TaxID=1965585 {ECO:0000313|EMBL:OUP05933.1, ECO:0000313|Proteomes:UP000195399};
RN   [1] {ECO:0000313|Proteomes:UP000195399}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An2 {ECO:0000313|Proteomes:UP000195399};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC       {ECO:0000256|ARBA:ARBA00008017}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUP05933.1}.
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DR   EMBL; NFJW01000034; OUP05933.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4HD63; -.
DR   Proteomes; UP000195399; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR   CDD; cd12912; PDC2_MCP_like; 1.
DR   Gene3D; 1.10.287.1260; -; 1.
DR   Gene3D; 2.30.30.60; -; 1.
DR   Gene3D; 3.30.70.100; -; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR049142; MS_channel_1st.
DR   InterPro; IPR023408; MscS_beta-dom_sf.
DR   InterPro; IPR006685; MscS_channel_2nd.
DR   InterPro; IPR011014; MscS_channel_TM-2.
DR   InterPro; IPR045276; YbiO_bact.
DR   PANTHER; PTHR30460:SF0; MODERATE CONDUCTANCE MECHANOSENSITIVE CHANNEL YBIO; 1.
DR   PANTHER; PTHR30460; UNCHARACTERIZED; 1.
DR   Pfam; PF21088; MS_channel_1st; 1.
DR   Pfam; PF00924; MS_channel_2nd; 1.
DR   SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR   SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000195399};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        287..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        341..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        619..640
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        699..718
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        743..763
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        784..806
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          788..828
FT                   /note="Mechanosensitive ion channel transmembrane helices
FT                   2/3"
FT                   /evidence="ECO:0000259|Pfam:PF21088"
FT   DOMAIN          829..893
FT                   /note="Mechanosensitive ion channel MscS"
FT                   /evidence="ECO:0000259|Pfam:PF00924"
FT   REGION          994..1031
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1031 AA;  112620 MW;  079AECF4871B196B CRC64;
     MTMPRTLTRI YTLKIALIVG AIAVSMLVMG ALLGGMQEQL TRASYDTEME AEATELKGLL
     ADAEDEAAQN KATFDAVYQA KAQALSYMAA NDTGFEATDA KMSEYRKLLD VDNVLVVKRD
     GTVVAKAART MADFSYMRFN YLRECLSTGE PSRAVEIELP EEDWLMRYYA ARLDADTMIV
     IEQSPAELRA LDAETSSIES VLRNVSVGQG GYVFALSAQT YLIEYHPDST LIGTDALDAG
     IDVAQLEDGA TAQLTLDGED LYCRVSLIGD TYYICAVPEA SLASARLVTV AVILFVFFAV
     ICTVTLYGVF VMHQEERDGN EDQHVVHLGR LRYNREIGRR AAIFSLVGFI AIVAVSFYMQ
     TLFALSTQSV VNKERAASIA ETIERVNDRA DDLTKQYDER YLSTARVAAY ILEANPELAT
     KAKMQELADA LQVSGVYLFN GSGDMVASNA PYEHFSLSKD KGDQSYAFWQ LLQGVDSLVQ
     EPMADEMTGE LVQYIGVATY DDAGYVNGFV QVIVHADRLE ELLSTVQIDH VLDGVKAGSG
     GFAFAVNKAD GTIAYYPDAS LVGKKATEVG LEDHQLRGGY DDYITVNGTT YYASSVETSD
     YYVYVAGPEG ELMAQRGPLT VATGAVALVC LVVTFFLVSF EPSHEPALLK AQESDPGAGR
     VFDIETPSGR RAKTESAASR WLNRSLDWNH MTPEQKLGYV LKLFVGVAVA AVFVSVLFKD
     QIFGSNSVFG YILGGGWERG LNIFAITASV MTACVIFTIS WVVQKVLHLL SDALSARGET
     VCRLLVSLTK YGAILGVLYW CLATVGVDTA TLLASAGLLT LAISFGAKDL VTDLLSGLFI
     IFEGEFRVGD TISVGSNTGT VMEIGIRTTK INDGNDNVIV LRNSAISNVV NRTKLDSFAL
     IDVDVAVGED LPHLENVLKE ALPRIAERQP MILDGPFYRG IVALTPTTMT VRVIARCAEK
     NRGALERNLK REMRLLLTRY DIAPYQLTFE HDDDIDACER PNESDELEGA DDFVESQDAS
     IGKYDGDKKK S
//