ID   A0A1Y4HL78_9BACT        Unreviewed;      1932 AA.
AC   A0A1Y4HL78;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 16.
DE   SubName: Full=Alpha-2-macroglobulin {ECO:0000313|EMBL:OUP06161.1};
GN   ORFNames=B5F34_14945 {ECO:0000313|EMBL:OUP06161.1};
OS   Mediterranea sp. An20.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Mediterranea.
OX   NCBI_TaxID=1965586 {ECO:0000313|EMBL:OUP06161.1, ECO:0000313|Proteomes:UP000196631};
RN   [1] {ECO:0000313|Proteomes:UP000196631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An20 {ECO:0000313|Proteomes:UP000196631};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUP06161.1}.
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DR   EMBL; NFJV01000033; OUP06161.1; -; Genomic_DNA.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000196631; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000196631}.
FT   DOMAIN          1169..1259
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1932 AA;  218226 MW;  D95E86D5E2EA6C69 CRC64;
     MKITKKLGSF LLLLWVTSMN LIWAQSYDKL WKQVEQAGKK GLPQTVIQLT DQIYEKGLQE
     HNAGQMLKAY VCRETYQERL TPDSLYTRLP QLEQWARSEK DAVNRAILYS LLAGDYADFV
     QRNRSALSNR TEVEGEMSGE DIRLWTARQL VDRIDACCTE ALRDSAALLA VSAEQYVPFV
     ELEEGSRFYG HDLYHLLVSR AVDTYRTVET WADSLAKERI DGIYKNQIEA YKNRPGRKDA
     LVLSTLDYWQ NDRERFLYNA PEGKTGEAYL DALDDLIARY GSRPVCADVY LAKAHWLYTG
     HPRRVAQALQ VCEEGIRRYA SYKRTNALRN LREDILQPYL SVSSGQIAYP GDSLDLRVDY
     RNLKGFTLHL YKTDLTSFDL PSEGFNQKFL QKHARRVASH HYDLQVLPLE GVPAEDWQYS
     QNDTTFRLPV PDELSLYVVQ VVPDDKRTEG RDRTYIVSSR LMVLTLSLPD NRMEVLALDR
     KTGHPVPGVT VAFYAASYNL SQDQKVTEVI TDADGRAVLT WNKKILSYVA RKDADVFLAP
     QRVYNNSYGR SVEESSECLS LLTDRSLYRP GQTIYVKGIA YEKGKESARV LEGRTYTVSL
     LDVNGKEVSK QEVRTNDFGS FSTEFMLPTS CLNGNFQLRV GNLATSTVRV EEYKRPTFTI
     TFDPVKEAYA WGDTVKLTGK VEAYNGAALQ MLPLAYTVTR HSGIWRGEDK ALAADTVQLD
     EEGRFSIPVF LEKASWMQTA NHAYFRVQAT VTGENGETQT EDRILNAWRW AYSFYSDLEG
     QVCKEDTLAA TFRVENADGQ LLEMEGTYRL YPVVDIKTGR TADAPMLQGT FTSGKRVVMD
     SSRLPSGYYQ VVLSVKATDG KEVDNREVNA ERFLLFSKRD RHLPVFMNDF IYEEQTAFDE
     EQPAVLYYGT SHNDAYVLVD IYNEQGRIEQ SVLQLNDTLT SLTYPYKEVY GKGVDITFSF
     VKNGQLYTRR VSLTKREPER KLSMKWEVFR DCLRPGQQEE WRLVVKNPQG LPAAAEVLAT
     MYDASLEQIY SRHQGLAVYF NRYIPYYNWQ AASSGRTAVT PYFPVKSAQV TGWLFDHFYV
     CYPRLYGGDN VIVSIADVKG VSNHSGVSRG YNAKRVMTGA VAPQADMVQE EMVEVTQLSE
     MEVTEEAGTA LDAGTLQPLE NLRTNFAETA FFYPQLRTNE QGELVFSFTA PESLTRWNFR
     GYSHTRDMLT GVLEGTATTS KEFMLMPNLP RFVRVGDKTH IAASITNLTA EKVKGTATLT
     LFDPLTDKVI TTLKDRFTVE AGRTEAVDFA FEVSDRYDLL GVRIVADGGE FSDGEQHVLP
     VLSNKTHVTE TLALPVRGEE TRTFSLDSLF NRHSRTATDR KLTVEFTGNP AWLAIQALPV
     LNEPVSEDAI SRATVWFANS LAAYIAASQP RIRSVFEAWK AQGGTKETLL SRLEQNPDLK
     NMLLSETPWL TEAQDESEQM ARLATLFDLN TLSLRLSSSL NRLQELQDGD GAWSWYPGMP
     GNRYVTGYVL NLLVRLPLLT GEALTDEAAL MRSKAFDFLH REIRRDYQRW LQQKPQVEIG
     HLSDFVLDYL YCLALSGEEI PAANREAYRY YLSKVPNELA TGSVMRKSEA LVILQKLGKK
     QQAEEFAASL REHLIQEDEL GAHFAFLDSP YRWGMMPIPT HVAAMEALRL QGGNDALLEE
     MKLWLLQQKK TTSWDTPVSA VNAIYALLCT GSNWLENRGD VRIEIGKETL ETQADASSVA
     GLSYVRRTYT EGSSAVKAKT VTVEKRDAGF AWGAVYAQYL SPMADLKQHG GELSVDKQLY
     LERVSADGSK SLVPLTGDVR LSVGDVVVSR ITIRLDRAMD FVHLKDSRAA CFEPVNALSG
     YRWGNIGYYE DVNDASTDFF FDSIGKGVYV LEHRDRVARS GSYETGIATM QCAYAPEYAS
     HSAGGTVLIE EP
//