ID A0A1Y4HP70_9ACTN Unreviewed; 1243 AA.
AC A0A1Y4HP70;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=B5F33_05520 {ECO:0000313|EMBL:OUP09246.1};
OS Collinsella sp. An2.
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC Coriobacteriaceae; Collinsella.
OX NCBI_TaxID=1965585 {ECO:0000313|EMBL:OUP09246.1, ECO:0000313|Proteomes:UP000195399};
RN [1] {ECO:0000313|Proteomes:UP000195399}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An2 {ECO:0000313|Proteomes:UP000195399};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUP09246.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NFJW01000006; OUP09246.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4HP70; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000195399; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000195399}.
FT DOMAIN 4..443
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 444..742
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 933..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 290..317
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1243 AA; 133080 MW; EC3FBD3F712AC4DB CRC64;
MDLSTLMPQQ LEIVKTLDGP LFVSAGAGSG KTFTLTQRIL WALSPESGPY VDHLDQVLAI
TFTKDAAAEI RERVRAALVK AGVEEEALRV DDAWISTIHG MCSRILRAHA LELGLDPEFS
VLGDPDELMD QAVEHVLARM QAEGRLPFHG GIRDWFALRG EVRPGGGEGG TSVVGIVRRL
LELSCALPHG MDDVHLARGY VDFSGLADAC RAYLADANPK SKGAQKAQEL LGRAEAIDAS
TATLDQVVEL LMNLDVPAAS GNAKAAATLI KAEAAEAVVN AYVALSSDAL DELLLFARNV
EAEYRRLKAE QSLLDNDDLL RLAFAALRDH ESVRAAYEGK FKLVMIDEFQ DTAQQQVDLI
DLLAGEGGIH LCTVGDAQQS IYRFRGADVE VFRRKEREIS RMSDAGADGI AGQDGAVSKD
AAAGQDAAGH GHIVRLIKNF RSHADILDYV AQVFDDGRGG IMRDFLDLVP NEGRADGLKA
QGASRRQAIF VAAQHTEDIR PALAASIARR FRELSDAGQP AGGMVLLLGG MTYADLYADA
IRAEGLDCVI AGGSVFSQAP EVSAVRALAC ALANPADTAQ GLALLLQSPM FSLGVQEFLA
LTTAWDSETG ETRRRNLDAG IASSDDAPGL AGLELVGRAR TVLRRAFSRV GRDPFARIAR
DVVNESGWFV RLADRGPEGK AVAANVLKAL DALGEAEAEL GNAPRKIVLA FDRFLAGKEA
PGALNEEGGD AVRIMTVHAS KGLEFPVVAV AECFSVRSDA SRFRVRRESD RVDAALLPSR
FPSITASDGS SISATAVEKQ FKKVTKWLND DLADEVCATG SALGAFNSFG EENLQLELAE
RARLLYVAMT RARELLILAM GERIGSEGKI PTLKFDERTD LTGRVLERIL PAWPSLATNR
LYYEGSQPGD FEFIPLSGFV FEDASYEAVE AATPEGEEPV GAPGAEDALP DDDGPMDTFT
LVEPVRVSVR TAPSPRPPRI SYSYTSMAAA LHAEDEDRAV AADAGEFADA LDAAGLGEGE
SVASLVASSD ADEVAPAPPV VDVVDATFGD DADEGAGAEP VSTAQAAVPE DPTALGSAFH
AAAQWLIETR QGTVPASRIA SLCAYWGVSE SQRARLLEAL GRWERSAVRR EVLSWPCVRA
EVPFFSEGMD GARERFGSYA EGSIDVLCTD PARPDEAFVV DYKTGGSASE MPEKLRDKHE
LQARVYADAL HRAGFARVTL TFVRVQIEDP SCPGEPQTVT YQF
//
