ID A0A1Y4I1L4_9FIRM Unreviewed; 1181 AA.
AC A0A1Y4I1L4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=B5F35_06550 {ECO:0000313|EMBL:OUP12920.1};
OS Anaeromassilibacillus sp. An200.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Anaeromassilibacillus.
OX NCBI_TaxID=1965587 {ECO:0000313|EMBL:OUP12920.1, ECO:0000313|Proteomes:UP000195336};
RN [1] {ECO:0000313|Proteomes:UP000195336}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An200 {ECO:0000313|Proteomes:UP000195336};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUP12920.1}.
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DR EMBL; NFJU01000009; OUP12920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4I1L4; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000195336; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:OUP12920.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000195336}.
FT DOMAIN 3..473
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 474..775
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1181 AA; 132161 MW; 5C1F425CA4B6B753 CRC64;
MARQWTPAQT DAIRARGGSL LVSAAAGSGK TAVLVERVLE RLTDPEHPTA ADRLLVVTFT
RAAAAEMSAR ISRQIALLLE ENPRDVHLQR QQIRMARAHI STIHSFCGDL VREFFYKLEI
SPDFRILDDS EMAVLRADAV EEVLEDYYGR GDEGFLALID AFAAGRDDSR IVRTVDTLYD
FIRSHPFPER WLQEKAAAYR DVTDPAQTQW GKTVLVFAEQ AVEYALSITD HSLLLLREAP
ELEAAYQEAY ASDRAGLLAL KETARSGDWD ETVFRCSSFS FARLKSVRGF SEDPVKLRVS
AARDEVKAVI KRLAGLFCAS REECAHDIAR LAPLVEKLFE VTMAYARALD AKKAERRAAD
FGDLEHWTLR LLWKDGENGP ELTPEAAEIA ARFDEVMVDE YQDTNEAQDM IFRAVSQREE
NLFMVGDVKQ SIYGFRQAMP QIFLRRRASF PLYDREQDRY PASVVLDRNF RSAKGITDAV
NFVFRQLMSR ETGDLDYGGL EELVPAASYP DSEEPAVELE LLDLADAEED EALAVQEGRR
IGALLLEHKE KTRVWEDGRE RPLRWSDVCV LLRSANRFAY EYARELQSLG IPARADASGG
FFAAREVSLA LSLLRCVDNP LLDIPLAAVL LSPIYGFTPG DLARVRLSDR HSCLYLAVQN
AAQEDERLAV FLRELAEFRG LAAALPSNRL LAELYDKTKL PELVQAMNGG ELRLANLRLL
LEYAGKYEES GHGGLSGFLR FLDRLERKKA DLAAAQQPGE QGDAVRIMSI HRSKGLEFPV
CVLAGCSRRF NKERGEVLLH PDLGLGVRLP DEETGVRYDV LPRQAAALEL DRDEMSEELR
VLYVAMTRAK QKLILLAGVK DAGRTLERLV PRLRQEEKLP PYTVRTCASI ADWLILCALR
HPSGGELRDQ GGALPGLMLP AAEPWLVRIT RPEPVARAES AQADAEAPDE AVLRQLRERI
AWQYPGRELT GVPSKVTASD LAERGLRREH WASSRPAFLG KGGLTPAERG TALHQFLQFA
DWEAARVSPD AELRRLRDGR YLTKEQADAV DLSRVKKFFS SRLAKRIFAS PRVLREYRFT
SELPAGVVRE GLSGEDAQKP VILQGVVDCA FVEDGALVVL DFKTDRVPDL GALLARYRAQ
LVLYRGALAQ CTGLPVRECV LYSFHLGDFL SFSGTEDEKT S
//
