ID   A0A1Y4IQI4_9FIRM        Unreviewed;       510 AA.
AC   A0A1Y4IQI4;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:OUP19911.1};
GN   ORFNames=B5F29_08010 {ECO:0000313|EMBL:OUP19911.1};
OS   Lachnoclostridium sp. An196.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1965583 {ECO:0000313|EMBL:OUP19911.1, ECO:0000313|Proteomes:UP000199780};
RN   [1] {ECO:0000313|Proteomes:UP000199780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An196 {ECO:0000313|Proteomes:UP000199780};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUP19911.1}.
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DR   EMBL; NFJZ01000005; OUP19911.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4IQI4; -.
DR   OrthoDB; 9762009at2; -.
DR   Proteomes; UP000199780; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR   CDD; cd09154; PLDc_SMU_988_like_1; 1.
DR   CDD; cd09160; PLDc_SMU_988_like_2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   InterPro; IPR022924; Cardiolipin_synthase.
DR   InterPro; IPR027379; CLS_N.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR   PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR   PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR   Pfam; PF13091; PLDc_2; 2.
DR   Pfam; PF13396; PLDc_N; 1.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199780};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        68..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          244..271
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          424..451
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   510 AA;  59086 MW;  8DAC04102D81357F CRC64;
     MKRIGRILTS RLVLVGLAII LQLAWFFFFM ERLTSYSVFI NGFFRVASIF VLLYLIRKDE
     SSAYKIAWII LVMGLPLFGG ILYLLIGNKK PSKNLAVHMA EVKGEMSEEL VQNEQILKEI
     EEHAPDVAGN IRYLGEYGPY PVWKNTQVKY YPVGEAMFAD MLRDLEKAEH YIFLEYYIIE
     EGIMWNTMLE ILERKVREGV DVRLIYDDVG CVSKLPYQYA QRMKEKGIKC MAFNRFVPFL
     SVVMNNRDHR KILVIDGHTA YNGGINLADE YINEKVRFGH WKDTGVRIYG EAVYSFTLMF
     LEMWNAFREP DLDYSIFRPR RWHTDSFESD GYVVPYADTP LDNEELGENV YINILNQAKD
     YVYIATPYLL ISDEMENALC LAAKRGVDVR ILMPGIPDKP VVFFMAKSYY PPLLNAGVQI
     YEYTPGFVHA KSYVCDDRIA TVGTINMDFR SLYLHFECGT FLYGCRAVLD VKKDMEDCFR
     QCHQVTFSDC RQGLLGNLFT SVLRVLAPLM
//