ID   A0A1Y4IU31_9FIRM        Unreviewed;       246 AA.
AC   A0A1Y4IU31;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB {ECO:0000313|EMBL:OUP22440.1};
GN   ORFNames=B5F29_01490 {ECO:0000313|EMBL:OUP22440.1};
OS   Lachnoclostridium sp. An196.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1965583 {ECO:0000313|EMBL:OUP22440.1, ECO:0000313|Proteomes:UP000199780};
RN   [1] {ECO:0000313|Proteomes:UP000199780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An196 {ECO:0000313|Proteomes:UP000199780};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUP22440.1}.
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DR   EMBL; NFJZ01000001; OUP22440.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4IU31; -.
DR   OrthoDB; 9794400at2; -.
DR   Proteomes; UP000199780; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd18103; SpoU-like_RlmB; 1.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   NCBIfam; TIGR00186; rRNA_methyl_3; 1.
DR   PANTHER; PTHR46429; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR   PANTHER; PTHR46429:SF1; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:OUP22440.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000199780};
KW   Transferase {ECO:0000313|EMBL:OUP22440.1}.
FT   DOMAIN          7..82
FT                   /note="RNA 2-O ribose methyltransferase substrate binding"
FT                   /evidence="ECO:0000259|SMART:SM00967"
SQ   SEQUENCE   246 AA;  26868 MW;  D19959C213099A87 CRC64;
     MRYEELTIEG RNAVLEAFRS GRTIDRLFVL KGCQDGPINS ILREARKRDT VISYVPRERL
     DHMSETGKHQ GVIAYAAAYE YAQVEDILQA AREKGEDPFL ILLDNIEDPH NLGAIIRTAN
     LAGAHGVIIP KRRAAGLTAT VAKASAGALN YTPVAKVTNL GTTIDELKKQ GIWFVCADMD
     GTVMYDVNLK GPIGLVIGNE GEGVSRLIRE KCDYQVSVPM KGDIDSLNAS VAAGVLAYEI
     VRQRRG
//