ID   A0A1Y4IYJ1_9FIRM        Unreviewed;      1082 AA.
AC   A0A1Y4IYJ1;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=B5F28_01750 {ECO:0000313|EMBL:OUP25434.1};
OS   Gemmiger sp. An194.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Gemmiger.
OX   NCBI_TaxID=1965582 {ECO:0000313|EMBL:OUP25434.1, ECO:0000313|Proteomes:UP000196090};
RN   [1] {ECO:0000313|Proteomes:UP000196090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An194 {ECO:0000313|Proteomes:UP000196090};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUP25434.1}.
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DR   EMBL; NFKA01000002; OUP25434.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4IYJ1; -.
DR   OrthoDB; 9758506at2; -.
DR   Proteomes; UP000196090; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR049035; ADDB_N.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   PANTHER; PTHR30591; RECBCD ENZYME SUBUNIT RECC; 1.
DR   PANTHER; PTHR30591:SF1; RECBCD ENZYME SUBUNIT RECC; 1.
DR   Pfam; PF21445; ADDB_N; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196090}.
FT   DOMAIN          267..556
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   COILED          434..462
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1082 AA;  117996 MW;  7ED257DF6EFDBD57 CRC64;
     MLHLVLGVSG SGKSSHLLQT IRTRALAGEK SVLIVPEQFT SSTEGRLYQL LGDELSGYVT
     SYSFTSLAED ILQAYGGAAV RTLTDAGRAV LVRRALQSMG PNLVYYSRHR RSAAFCEKCA
     ETLDEFKSAG LSPRQLEELA QNTGHSSRKL GELAGIFAAY EALLEGSAMD PGDRVLAAAK
     ALQPDFFAGR AVFIDEFDTF NAPKRRLLEA MLTMAEDVTV ALCCDGLEDY EGGLGLFSGA
     KQMAAALRQL ARKNSVPVAA PLVLDNDFRH SEAPDLARLN RLLSGQLEDP APASETQLTL
     WQAPTRADEA KQVAAAIQAL ARQGVPYGKM AVICRDSENY LAPIRYEFRL AGIPLFCDEA
     TTAEHAAPVR LVRALLALLR RGLCTDNLLA VAKTGLTSLT EPQLCALENY AYTWQLSAAQ
     WRQPFTLSPA GFGANTLSEK AKKEQEEQLA LAEEARAFLV DELDGFAARC KDLPASQVCA
     ALYKRMQALG GEEAMGRMCA ELKESEGIPA ASEAVRVWNL TADLLNQMAL LLGEEVLPAA
     ELADLFELLV RSTDLGHIPQ TLDQVIFTTA GRMRLDNPDW CFVLGLAEGE FPKAPGDKGL
     LTHAERESLM RQGVEMPDCF ENRAIREQVC FYKALTAPAK GLWLSWAAGS AAMPVTSALA
     PVIECFSPKE PALERADLAA TPAMALDLLG QSWDAESGET AALFQSLAEY RDEAEQGKLL
     NPVKQAAGAE PFAVHNTAAM KQLLGRELWL TPSRMERYYS CPFAYFLEYV LGAKPRKQAA
     LTADQSGNLV HYILEQALRR AGEGFVDLSE EQVKALAAAI AEEYVQENMP GQARRFGYLV
     ERLKKSAANL LLYIQAEQRQ GSFVPVAFEK GIGTSPEDVP PVVLTTSTGE TVRMVGKIDR
     VDAFEKNGNT WLRVVDYKTG SKEFLLEDVK NGLNCQMLVY LFTLTRNGGQ QFADPAPAGV
     LYLMADPAPT RGSRQQAAKG LEYKVEGLVA DEYAVIDAMD RERKGLFVPF KFDKDGTPKP
     GPALASLETL DGLRQELDGL VVQMAERLYA GQVAAEPIGH GKRKETNCKY CDYRSVCGHE
     DD
//