ID   A0A1Y4K0N4_9ACTN        Unreviewed;       873 AA.
AC   A0A1Y4K0N4;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN   ORFNames=B5F23_07070 {ECO:0000313|EMBL:OUP38328.1};
OS   Olsenella sp. An188.
OC   Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC   Olsenella.
OX   NCBI_TaxID=1965579 {ECO:0000313|EMBL:OUP38328.1, ECO:0000313|Proteomes:UP000196278};
RN   [1] {ECO:0000313|Proteomes:UP000196278}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An188 {ECO:0000313|Proteomes:UP000196278};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC       alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC       ECO:0000256|PIRNR:PIRNR000111}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC       dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC       ECO:0000256|PIRNR:PIRNR000111}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUP38328.1}.
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DR   EMBL; NFKF01000005; OUP38328.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4K0N4; -.
DR   OrthoDB; 323926at2; -.
DR   Proteomes; UP000196278; Unassembled WGS sequence.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR   CDD; cd08178; AAD_C; 1.
DR   CDD; cd07122; ALDH_F20_ACDH; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR034789; AAD_C.
DR   InterPro; IPR001670; ADH_Fe/GldA.
DR   InterPro; IPR018211; ADH_Fe_CS.
DR   InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012079; Bifunc_Ald-ADH.
DR   PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   Pfam; PF00465; Fe-ADH; 1.
DR   PIRSF; PIRSF000111; ALDH_ADH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR   PROSITE; PS00913; ADH_IRON_1; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR000111}.
FT   DOMAIN          12..273
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   DOMAIN          460..851
FT                   /note="Alcohol dehydrogenase iron-type/glycerol
FT                   dehydrogenase GldA"
FT                   /evidence="ECO:0000259|Pfam:PF00465"
SQ   SEQUENCE   873 AA;  95637 MW;  8FE638C76540CC30 CRC64;
     MADNVQTTID SVEALQERIK QMRAAQAEFA KFTQEQVDKI FYEAAMAANK ARIPLAKMAV
     EETGYGIMED KVIKNHYASE YIYNKYKNMR TCDVISDDKA FGYKQVAEPL GLVAAVIPTT
     NPTSTAIFKT LICLKTRNAI LISPHPRAKK CTAEAARIVR DAAEAAGCPK GIIDWIDVPS
     LDMTAELMRS ADIILATGGP GMVNAAYSSG KPALGVGPGN NPAIIDDTAD VELSVNSIIH
     SKTFDNGMIC ATEQNVIVLD KIYDAVKAEF QKRGCYFLQG EEIAKVGNTV IVNGGVNAKM
     VGQPAPKIAE AAGVEVPAST KVLIGEVESV EPSEPWAHEK LTTILGMYRA SDWEDALSKA
     ERLIADGGYG HTSSLFIDTR ETEKMAEHAK RMKTCRILIN TPAAQGGIGD IYNFKMAPSL
     TLGCGSWGGN SVSGNVGPQH LLNIKSVAER RENMLWFRVP EKVFFKKGCM PVALRELSEV
     YGKKRAFIVT DSFLYKSGFT KKIEESLDEQ GIVYSSFWSI SPDPKLQDCE KGLEQLKAFE
     PDCIIAIGGG SAMDAGKIMW MMYEHPEAKF EDMAMDFMDI RKRVYTFPEM GQKAFFVAIP
     TSSGTGSEVT PFSIITDANT GTKWPIADYQ LLPNMAIVDT DNMMTQPKGL TAASGVDVLT
     HALEAYVSVM SSDYTDGLAL RAMKLVLEYL ERAYDDGTDV EARDHMANAS CLAGMAFANA
     FLGVNHSMAH KLGAYHHIAH GLANAVILTR VMRYNAAERP VKMGTFPQYD HPKTLARYAE
     AGRFCGITGK DDREVFENFV ARIEELKAHV GVPETIAGFG VTEEDFLATI DEMSENAFND
     QCTGANPRYP LVSEIKELYL DAFYGREATS YED
//