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Database: UniProt
Entry: A0A1Y4K561_9ACTN
LinkDB: A0A1Y4K561_9ACTN
Original site: A0A1Y4K561_9ACTN 
ID   A0A1Y4K561_9ACTN        Unreviewed;       342 AA.
AC   A0A1Y4K561;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   08-MAY-2019, entry version 8.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=B5F23_02440 {ECO:0000313|EMBL:OUP39855.1};
OS   Olsenella sp. An188.
OC   Bacteria; Actinobacteria; Coriobacteriia; Coriobacteriales;
OC   Atopobiaceae; Olsenella.
OX   NCBI_TaxID=1965579 {ECO:0000313|EMBL:OUP39855.1};
RN   [1] {ECO:0000313|EMBL:OUP39855.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An188 {ECO:0000313|EMBL:OUP39855.1};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T.,
RA   Cizek A., Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OUP39855.1}.
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DR   EMBL; NFKF01000001; OUP39855.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       37    334       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   342 AA;  38274 MW;  567BDB6DE227E44B CRC64;
     MSMKFKRLLP IPKDIRAEMP LSDEMARRKE EFDARVAAVL SGEDPRRLLI IGPCSADRED
     SVLDYATRLA ALAERVSDKL VVVPRVYTNK PRTKGIGYKG LLHNPNPEAG DDLLEGVKAI
     RHMHLRVVEE TGLFTADEML YPTNYQYLID LLAYIAVGAR SVENQEHRLV ASGVPMPVGM
     KNPTGGSTDV MLNSIYAAQQ PQTFIFRNWE VSTTGNPLAH AVLRGYVGLD GINYPNYHYE
     YLERLAEKYT LASFENPAVV IDCNHDNSGK RPFQQIRICH EVMDSVRRSD AIGRLVRGFM
     VESYLVDGNQ PVGGGTYGQS ITDACIGWEK TERLVLEIAE RS
//
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