ID A0A1Y4KVK4_9FIRM Unreviewed; 406 AA.
AC A0A1Y4KVK4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Recombinase XerC {ECO:0000313|EMBL:OUP48677.1};
GN ORFNames=B5F18_11155 {ECO:0000313|EMBL:OUP48677.1};
OS Lachnoclostridium sp. An181.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=1965575 {ECO:0000313|EMBL:OUP48677.1, ECO:0000313|Proteomes:UP000242090};
RN [1] {ECO:0000313|Proteomes:UP000242090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An181 {ECO:0000313|Proteomes:UP000242090};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC {ECO:0000256|ARBA:ARBA00008857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUP48677.1}.
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DR EMBL; NFKJ01000023; OUP48677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4KVK4; -.
DR OrthoDB; 9803188at2; -.
DR Proteomes; UP000242090; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008907; F:integrase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd01189; INT_ICEBs1_C_like; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004191; Integrase_Tn916-type_DNA-bd_N.
DR PANTHER; PTHR30629; PROPHAGE INTEGRASE; 1.
DR PANTHER; PTHR30629:SF2; PROPHAGE INTEGRASE INTS-RELATED; 1.
DR Pfam; PF02920; Integrase_DNA; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000242090};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 72..152
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 174..397
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
SQ SEQUENCE 406 AA; 47028 MW; E8ADADB4BF071236 CRC64;
MAVSRKDPKG RKLREGESWR NDGRYSYRFT DIRTGKRRTI YAQDLPELRE KEKKIAKDMD
DNILTDSAIK KMTLNTLFER YMATRELKEP TRVNYIRVWN NRVKDEIGNI KVVQMLPSHI
KAYYSKLSKA GYAHSTIKYI NNMIFPALEM AVDDDIIRKN PAKGSISDYG RPAEERVALT
ISQQEKLIDF VKQSNVYNTY YPMLTIMIGT GLRCGELIGL TWKDVDTRAR RLNVDHQLIY
KNYGDGCRFH ISTPKTDSGI RVIPMTQEVQ KAFEEQRKIN FMLAKDKSYE VDGYSGFVFT
AKSGRPLMPY GVNSVLYNIV DAYNKAEVQK AKKEHRKAEL LPKVSAHVMR HTACTRMAEC
RMDIKVLQYI MGHAHFDVTM EVYNHLGDRA RIENEIAKLD SMAVNF
//
