ID   A0A1Y4LHA3_9FIRM        Unreviewed;       437 AA.
AC   A0A1Y4LHA3;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   ORFNames=B5F19_10455 {ECO:0000313|EMBL:OUP54909.1};
OS   Pseudoflavonifractor sp. An184.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Pseudoflavonifractor.
OX   NCBI_TaxID=1965576 {ECO:0000313|EMBL:OUP54909.1, ECO:0000313|Proteomes:UP000196588};
RN   [1] {ECO:0000313|Proteomes:UP000196588}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An184 {ECO:0000313|Proteomes:UP000196588};
RA   Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA   Rychlik I.;
RT   "Function of individual gut microbiota members based on whole genome
RT   sequencing of pure cultures obtained from chicken caecum.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OUP54909.1}.
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DR   EMBL; NFKI01000029; OUP54909.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y4LHA3; -.
DR   OrthoDB; 305360at2; -.
DR   Proteomes; UP000196588; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196588};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        86..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        160..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        316..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        352..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        386..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   437 AA;  46507 MW;  E6AE3B7997C791BA CRC64;
     MTNTQRKEIP RYVFPAVGGL FMTYLYNVVD GIFVGQGVGA AALGAVNIGV PFITSVVAIA
     AMFPMGGATV VAIRMGRGDE KGANQAFMTS VVLTLLVSAI LTVVGMVFAG PIVDLSGGAQ
     LSREMRDMAV DYLFYYSAFS IPMLMSTCLS TFVRNDGSPA LSFLGMAVGA VANIFLDWLF
     IFPFQMGVIG AAVASGLGQI SAVLVLLTHF IRKRGSLRLS GFHLSAPLMG KICKRGVPEA
     VSQLNTPVTA FCYNLVLAHL VGDMGVSTFS VLSFIYSLAN AILSGVAQGL QPLWGNHYGQ
     KDTGGLKSLL RDGITINAAL SVLVYGFLFL LAVPVIRIFN QEPALVDAAS KALPLFALSF
     IPMALNLIFT AYFYSTKRTV QADVIAVSRG IVVKAACIFL MPALLGEGVI WLAPLAAECI
     TLVLSIFFNR CSQLAYR
//