ID A0A1Y4LQZ7_9FIRM Unreviewed; 1204 AA.
AC A0A1Y4LQZ7;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=B5F19_02905 {ECO:0000313|EMBL:OUP58260.1};
OS Pseudoflavonifractor sp. An184.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Pseudoflavonifractor.
OX NCBI_TaxID=1965576 {ECO:0000313|EMBL:OUP58260.1, ECO:0000313|Proteomes:UP000196588};
RN [1] {ECO:0000313|Proteomes:UP000196588}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An184 {ECO:0000313|Proteomes:UP000196588};
RA Medvecky M., Cejkova D., Polansky O., Karasova D., Kubasova T., Cizek A.,
RA Rychlik I.;
RT "Function of individual gut microbiota members based on whole genome
RT sequencing of pure cultures obtained from chicken caecum.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OUP58260.1}.
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DR EMBL; NFKI01000004; OUP58260.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y4LQZ7; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000196588; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014152; AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02785; addA_Gpos; 1.
DR PANTHER; PTHR11070:SF48; ATP-DEPENDENT HELICASE_NUCLEASE SUBUNIT A; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000313|EMBL:OUP58260.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000196588}.
FT DOMAIN 3..482
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 509..790
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1006..1027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1204 AA; 134082 MW; 8DDFDFA4A14C2F4F CRC64;
MAFPLTDEQK KIVDDRGGEL LVSAAAGSGK TRVLVERLLD RVTREGLDLD RFLVITYTKA
AAAELRTRIA QELSSRLAEN PGDRHLRRQS TLVYRAQIST IHSFCSALLR EEGHRLDLDP
DFRLCDEGEA QVLMAQVLED VLEAQYEGIK PDSPFAVLVD TLSAGRDDSR LAQIVLDVFG
RIQSHPHPER WLREQREVWE LSGVTDAGET AWGRLLLTDA ARQGRDCAKR LEEALALTAA
DELLEGNYAP SLQATLEGVE AFCAAAEGGS WDRAFACLPI PFPAVGRKRK RTVELSPMEE
ARALAATQRV KDLRDAVKER FGKLSDWFDG DSGEQLAALA ESRPAVQGLM DLVGTFQGAY
QAEKARRGLL DFSDLEHFAV RLLTDPETGE PTQLARSWSA RYAEVMVDEY QDTNQVQNAI
FSAVSDGGRK LFQVGDVKQS IYRFRLADPT IFLGKYRSFP DGDEAAEGEP RRRVLSRNFR
SRRQVLEGCN DLFRNIMSTE FGELDYTDDQ ALVPEGKFPE REHKELELDL LDLSFLGDQE
EGEREDKNRL EARWAARRIR ALLDQPLMVK EGDGERPLRP SDVMILLRSP GVVMHHYLRE
LSQAGVPWRA DSGGDFFETT EVNVALALLQ IVDNPRQDVP LIAALRSPLY GFDGDKLALL
RAGSKSGDFY SAVVRAAQEG DGECRDFLEE LEELRFGAGD MTCRQLIWHI YEKTNLLGLF
GAMPGGQERQ DNLLSLYALA GELEDSGCRS LFQFLLRLER IRAAGGKFSA ASSAREGEGV
SILSIHRSKG LECPVVLVCG LSRRFNRDDL MRPVLFHAQL GVGPKGLDRE RMVEYPTLAR
RAVARQLERE MMAEELRLLY VAMTRAQEKL ILSIALTEGL KALERLAGEA DAPVAPAALE
RQQSVGAWIL LHALTRPEAE GLRAMCGAPE RSAQGLGPAW DIRWVEGAGL RAASQPEGRF
ADLPAAEQDG EAGELMEALT WRYPYGAASE MPSKLTATQL KGRVLDQEAA EETPKPREHR
PESIQRPDFI AREKGLTPTE RGTALHLAMQ YLPLNGDHSP EGIRRELDRL AAGGFLTHLQ
REAVDPAVPA AFFASDLGKQ LLASPEIHRE FKFSILTPAS DYGPGLEGEE VLLQGVIDCW
FAEGDGLTVL DFKSDRIRPG GEGTRAEEYR PQLEAYSRAL ERVTGRKVFR RVLWFFATGQ
PWEL
//
